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Gene: RORC (RAR related orphan receptor C) Homo sapiens
Symbol: RORC
Name: RAR related orphan receptor C
Description: Exhibits DNA-binding transcription factor activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and oxysterol binding activity. Involved in cellular response to sterol and negative regulation of transcription by RNA polymerase II. Localizes to the nuclear body. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; RORG; RZR-GAMMA; RZRG; TOR
Mus musculus (house mouse) : Rorc (RAR-related orphan receptor gamma)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rorc (RAR-related orphan receptor C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rorc (RAR related orphan receptor C)
Pan paniscus (bonobo/pygmy chimpanzee) : RORC (RAR related orphan receptor C)
Canis lupus familiaris (dog) : RORC (RAR related orphan receptor C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rorc (RAR related orphan receptor C)
Sus scrofa (pig) : RORC (RAR related orphan receptor C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381151,806,071 - 151,832,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371151,778,547 - 151,804,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,045,171 - 150,070,972 (-)NCBINCBI36hg18NCBI36
Build 341148,591,621 - 148,617,421NCBI
Celera1124,893,230 - 124,919,042 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1123,155,515 - 123,181,337 (-)NCBIHuRef
CHM1_11153,173,871 - 153,199,672 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RORC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317896
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.