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Gene: PLEK (pleckstrin) Homo sapiens
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Symbol: PLEK
Name: pleckstrin
CRRD ID: 1317946
Description: Exhibits phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin cytoskeleton organization; and positive regulation of supramolecular fiber organization. Localizes to cytoplasm and ruffle membrane; INTERACTS WITH all-trans-retinoic acid; antirheumatic drug; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ27168; P47; platelet 47 kDa protein
Orthologs:
Mus musculus (house mouse) : Plek (pleckstrin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plek (pleckstrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plek (pleckstrin)
Pan paniscus (bonobo/pygmy chimpanzee) : PLEK (pleckstrin)
Canis lupus familiaris (dog) : PLEK (pleckstrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plek (pleckstrin)
Sus scrofa (pig) : PLEK (pleckstrin)
Chlorocebus sabaeus (African green monkey) : PLEK (pleckstrin)
Heterocephalus glaber (naked mole-rat) : Plek (pleckstrin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl268,365,282 - 68,397,453 (+)EnsemblGRCh38hg38GRCh38
GRCh38268,365,282 - 68,397,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37268,592,322 - 68,624,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,445,826 - 68,478,089 (+)NCBINCBI36hg18NCBI36
Build 34268,504,074 - 68,536,233NCBI
Celera268,441,906 - 68,474,166 (+)NCBI
Cytogenetic Map2p14NCBI
HuRef268,329,667 - 68,361,928 (+)NCBIHuRef
CHM1_1268,523,094 - 68,555,363 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PLEK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317946
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.