HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor) - Chinchilla Research Resource Database
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Gene: HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor) Homo sapiens
Analyze
Symbol: HIF1AN
Name: hypoxia inducible factor 1 subunit alpha inhibitor
CRRD ID: 1317966
Description: Exhibits several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Localizes to cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus; PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2-hydroxypropanoic acid; 5-chloro-7-iodoquinolin-8-ol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp762F1811; factor inhibiting HIF-1; factor inhibiting HIF1; FIH-1; FIH1; FLJ20615; FLJ22027; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10100,529,072 - 100,559,998 (+)EnsemblGRCh38hg38GRCh38
GRCh3810100,535,921 - 100,559,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710102,295,641 - 102,313,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,285,631 - 102,303,671 (+)NCBINCBI36hg18NCBI36
Build 3410102,285,685 - 102,299,745NCBI
Celera1096,033,472 - 96,051,511 (+)NCBI
Cytogenetic Map10q24.31NCBI
HuRef1095,924,437 - 95,942,312 (+)NCBIHuRef
CHM1_110102,580,289 - 102,598,327 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model



Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11641274   PMID:11823643   PMID:11959990   PMID:12042299   PMID:12080085   PMID:12215170   PMID:12432100   PMID:12446723   PMID:12477932   PMID:12482756   PMID:14701857   PMID:14702039  
PMID:14734545   PMID:15239670   PMID:15280364   PMID:15489334   PMID:16189267   PMID:16189514   PMID:16385451   PMID:17003112   PMID:17135241   PMID:17244529   PMID:17382325   PMID:17573339  
PMID:17636018   PMID:17682059   PMID:18096060   PMID:18280659   PMID:18299578   PMID:18398039   PMID:18611856   PMID:18676680   PMID:18927305   PMID:18936059   PMID:19060904   PMID:19071119  
PMID:19074848   PMID:19134330   PMID:19170196   PMID:19245366   PMID:19322201   PMID:19401150   PMID:19615732   PMID:19625176   PMID:19692168   PMID:19696166   PMID:19726677   PMID:19940151  
PMID:20145132   PMID:20453000   PMID:20720525   PMID:20727020   PMID:21069436   PMID:21177872   PMID:21251231   PMID:21443853   PMID:21732131   PMID:21808058   PMID:21873635   PMID:22002313  
PMID:22532441   PMID:22645313   PMID:22891326   PMID:23351038   PMID:23362303   PMID:23606740   PMID:24100311   PMID:24337577   PMID:24388053   PMID:24465898   PMID:24521875   PMID:24867948  
PMID:25320245   PMID:25347788   PMID:25351569   PMID:25413349   PMID:25423620   PMID:25431923   PMID:25609649   PMID:25687434   PMID:25728779   PMID:25837583   PMID:25907805   PMID:26112411  
PMID:26186194   PMID:26205124   PMID:26673895   PMID:26749281   PMID:26751287   PMID:26752685   PMID:26948053   PMID:26972000   PMID:27107014   PMID:27173435   PMID:27815979   PMID:28061479  
PMID:28514442   PMID:29047187   PMID:29056521   PMID:29259012   PMID:29371964   PMID:29426014   PMID:29737085   PMID:30004795   PMID:30082910   PMID:30237125   PMID:30333145   PMID:31299612  
PMID:31515488   PMID:32296183  


Genomics

Comparative Map Data
HIF1AN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10100,529,072 - 100,559,998 (+)EnsemblGRCh38hg38GRCh38
GRCh3810100,535,921 - 100,559,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710102,295,641 - 102,313,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,285,631 - 102,303,671 (+)NCBINCBI36hg18NCBI36
Build 3410102,285,685 - 102,299,745NCBI
Celera1096,033,472 - 96,051,511 (+)NCBI
Cytogenetic Map10q24.31NCBI
HuRef1095,924,437 - 95,942,312 (+)NCBIHuRef
CHM1_110102,580,289 - 102,598,327 (+)NCBICHM1_1
Hif1an
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,551,293 - 44,564,713 (+)NCBI
GRCm381944,562,854 - 44,576,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,562,850 - 44,576,274 (+)EnsemblGRCm38mm10GRCm38
MGSCv371944,637,344 - 44,650,764 (+)NCBIGRCm37mm9NCBIm37
MGSCv361944,616,165 - 44,629,585 (+)NCBImm8
Celera1945,330,539 - 45,343,961 (+)NCBICelera
Cytogenetic Map19C3NCBI
Hif1an
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01264,309,214 - 264,319,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,309,214 - 264,319,267 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,752,379 - 271,762,022 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,607,945 - 249,618,000 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11249,868,052 - 249,878,559 (+)NCBI
Celera1239,233,319 - 239,243,566 (+)NCBICelera
Cytogenetic Map1q54NCBI
Hif1an
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,592,106 - 9,602,019 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554859,592,106 - 9,602,019 (-)NCBIChiLan1.0ChiLan1.0
HIF1AN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110100,616,208 - 100,634,201 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,616,208 - 100,628,470 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01097,135,751 - 97,148,378 (+)NCBI
HIF1AN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2813,258,765 - 13,267,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12813,253,646 - 13,277,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hif1an
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366005,106,166 - 5,116,865 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIF1AN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,636,376 - 111,652,527 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,636,317 - 111,654,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,295,774 - 121,311,992 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIF1AN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl993,557,055 - 93,569,035 (+)Ensembl
ChlSab1.1993,557,143 - 93,569,301 (+)NCBI
Hif1an
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
A007K11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710102,313,406 - 102,313,548UniSTSGRCh37
Build 3610102,303,396 - 102,303,538RGDNCBI36
Celera1096,051,236 - 96,051,378RGD
Cytogenetic Map10q24UniSTS
HuRef1095,942,037 - 95,942,179UniSTS
GeneMap99-GB4 RH Map10467.43UniSTS
NCBI RH Map101089.7UniSTS
STS-W37897  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710102,309,525 - 102,309,739UniSTSGRCh37
Build 3610102,299,515 - 102,299,729RGDNCBI36
Celera1096,047,355 - 96,047,569RGD
Cytogenetic Map10q24UniSTS
HuRef1095,938,156 - 95,938,370UniSTS
GeneMap99-GB4 RH Map10471.99UniSTS
MARC_15337-15338:1017677542:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710102,306,932 - 102,308,151UniSTSGRCh37
Build 3610102,296,922 - 102,298,141RGDNCBI36
Celera1096,044,762 - 96,045,981RGD
HuRef1095,935,565 - 95,936,784UniSTS
HIF1AN_3604  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710102,308,953 - 102,309,855UniSTSGRCh37
Build 3610102,298,943 - 102,299,845RGDNCBI36
Celera1096,046,783 - 96,047,685RGD
HuRef1095,937,584 - 95,938,486UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR31hsa-miR-31-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI22532441
MIR31hsa-miR-31-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR31hsa-miR-31-5pOncomiRDBexternal_infoNANA20145132

Predicted Target Of
Summary Value
Count of predictions:6005
Count of miRNA genes:1386
Interacting mature miRNAs:1884
Transcripts:ENST00000299163, ENST00000478787, ENST00000526476, ENST00000528044, ENST00000533589
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1475 1254 710 88 1174 54 3007 1560 942 188 1166 897 51 1 119 2275 5 2
Low 964 1725 1016 536 767 411 1350 635 2792 231 294 716 124 1085 513 1
Below cutoff 12 10 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000299163   ⟹   ENSP00000299163
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10100,535,943 - 100,559,998 (+)Ensembl
RefSeq Acc Id: ENST00000478787
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10100,536,470 - 100,545,497 (+)Ensembl
RefSeq Acc Id: ENST00000526476   ⟹   ENSP00000432791
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10100,535,915 - 100,545,968 (+)Ensembl
RefSeq Acc Id: ENST00000528044
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10100,536,198 - 100,540,728 (+)Ensembl
RefSeq Acc Id: ENST00000533589   ⟹   ENSP00000433360
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10100,529,072 - 100,546,581 (+)Ensembl
RefSeq Acc Id: NM_017902   ⟹   NP_060372
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810100,535,943 - 100,559,998 (+)NCBI
GRCh3710102,295,641 - 102,313,681 (+)ENTREZGENE
Build 3610102,285,631 - 102,303,671 (+)NCBI Archive
HuRef1095,924,437 - 95,942,312 (+)ENTREZGENE
CHM1_110102,580,289 - 102,598,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539940   ⟹   XP_011538242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810100,535,933 - 100,553,920 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539941   ⟹   XP_011538243
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810100,535,921 - 100,553,920 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_060372   ⟸   NM_017902
- UniProtKB: Q9NWT6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011538243   ⟸   XM_011539941
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011538242   ⟸   XM_011539940
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000433360   ⟸   ENST00000533589
RefSeq Acc Id: ENSP00000299163   ⟸   ENST00000299163
RefSeq Acc Id: ENSP00000432791   ⟸   ENST00000526476
Protein Domains
JmjC

Promoters
RGD ID:7218433
Promoter ID:EPDNEW_H14962
Type:multiple initiation site
Name:HIF1AN_1
Description:hypoxia inducible factor 1 alpha subunit inhibitor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810100,535,943 - 100,536,003EPDNEW
RGD ID:6787751
Promoter ID:HG_KWN:10865
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017902,   OTTHUMT00000049866
Position:
Human AssemblyChrPosition (strand)Source
Build 3610102,285,361 - 102,285,861 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q24.2-24.31(chr10:99386632-100648221)x3 copy number gain See cases [RCV000135650] Chr10:99386632..100648221 [GRCh38]
Chr10:101146389..102407978 [GRCh37]
Chr10:101136379..102397968 [NCBI36]
Chr10:10q24.2-24.31
uncertain significance
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss PARP Inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q24.31(chr10:101932457-102392841)x3 copy number gain not provided [RCV001006350] Chr10:101932457..102392841 [GRCh37]
Chr10:10q24.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17113 AgrOrtholog
COSMIC HIF1AN COSMIC
Ensembl Genes ENSG00000166135 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000299163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000432791 UniProtKB/TrEMBL
  ENSP00000433360 UniProtKB/TrEMBL
Ensembl Transcript ENST00000299163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000526476 UniProtKB/TrEMBL
  ENST00000533589 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1010 UniProtKB/Swiss-Prot
GTEx ENSG00000166135 GTEx
HGNC ID HGNC:17113 ENTREZGENE
Human Proteome Map HIF1AN Human Proteome Map
InterPro Cupin_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIH-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIH-1_dom_II UniProtKB/Swiss-Prot
  JmjC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55662 UniProtKB/Swiss-Prot
NCBI Gene 55662 ENTREZGENE
OMIM 606615 OMIM
PANTHER PTHR12461:SF51 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cupin_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29284 PharmGKB
PROSITE JMJC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART JmjC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.500788 ENTREZGENE
UniProt E9PL41_HUMAN UniProtKB/TrEMBL
  E9PNR8_HUMAN UniProtKB/TrEMBL
  HIF1N_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3DR69 UniProtKB/Swiss-Prot
  Q5W147 UniProtKB/Swiss-Prot
  Q969Q7 UniProtKB/Swiss-Prot
  Q9NPV5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 HIF1AN  hypoxia inducible factor 1 subunit alpha inhibitor    hypoxia inducible factor 1 alpha subunit inhibitor  Symbol and/or name change 5135510 APPROVED
2016-02-18 HIF1AN  hypoxia inducible factor 1 alpha subunit inhibitor    hypoxia inducible factor 1, alpha subunit inhibitor  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.