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Gene: NUDT15 (nudix hydrolase 15) Homo sapiens
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Symbol: NUDT15
Name: nudix hydrolase 15
Description: Exhibits 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; and nucleoside-diphosphatase activity. Involved in several processes, including DNA protection; dGTP catabolic process; and exogenous drug catabolic process. Predicted to localize to the cytosol. Implicated in thiopurine S-methyltransferase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; FLJ10956; MGC104352; MTH2; mutT homolog 2; nucleoside diphosphate-linked moiety X motif 15; nucleoside diphosphate-linked to another moiety X hydrolase 15; nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix motif 15; nudix-type motif 15; NUDT15D; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1
Orthologs:
Mus musculus (house mouse) : Nudt15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nudt15 (nudix hydrolase 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nudt15 (nudix hydrolase 15)
Pan paniscus (bonobo/pygmy chimpanzee) : NUDT15 (nudix hydrolase 15)
Canis lupus familiaris (dog) : NUDT15 (nudix hydrolase 15)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nudt15 (nudix hydrolase 15)
Sus scrofa (pig) : NUDT15 (nudix hydrolase 15)
more info ...
Related Pseudogenes: NUDT15P1   NUDT15P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,037,567 - 48,052,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,611,703 - 48,621,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,509,704 - 47,519,283 (+)NCBINCBI36hg18NCBI36
Build 341347,509,703 - 47,519,283NCBI
Celera1329,666,454 - 29,676,033 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,404,604 - 29,414,174 (+)NCBIHuRef
CHM1_11348,579,420 - 48,594,612 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NUDT15
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317982
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.