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Gene: NUDT15 (nudix hydrolase 15) Homo sapiens
Symbol: NUDT15
Name: nudix hydrolase 15
Description: Exhibits 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; and nucleoside-diphosphatase activity. Involved in several processes, including DNA protection; dGTP catabolic process; and exogenous drug catabolic process. Predicted to localize to the cytosol. Implicated in thiopurine S-methyltransferase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; FLJ10956; MGC104352; MTH2; mutT homolog 2; nucleoside diphosphate-linked moiety X motif 15; nucleoside diphosphate-linked to another moiety X hydrolase 15; nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; nudix motif 15; nudix-type motif 15; NUDT15D; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15; RP11-90M2.1
Mus musculus (house mouse) : Nudt15 (nudix (nucleoside diphosphate linked moiety X)-type motif 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nudt15 (nudix hydrolase 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nudt15 (nudix hydrolase 15)
Pan paniscus (bonobo/pygmy chimpanzee) : NUDT15 (nudix hydrolase 15)
Canis lupus familiaris (dog) : NUDT15 (nudix hydrolase 15)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nudt15 (nudix hydrolase 15)
Sus scrofa (pig) : NUDT15 (nudix hydrolase 15)
more info ...
Related Pseudogenes: NUDT15P1   NUDT15P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381348,037,567 - 48,052,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,611,703 - 48,621,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,509,704 - 47,519,283 (+)NCBINCBI36hg18NCBI36
Build 341347,509,703 - 47,519,283NCBI
Celera1329,666,454 - 29,676,033 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,404,604 - 29,414,174 (+)NCBIHuRef
CHM1_11348,579,420 - 48,594,612 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NUDT15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317982
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.