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Gene: Nhlh2 (nescient helix loop helix 2) Mus musculus
Symbol: Nhlh2
Name: nescient helix loop helix 2
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mating behavior; ovulation cycle; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Orthologous to human NHLH2 (nescient helix-loop-helix 2); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6230401I09Rik; bHLHa; bHLHa34; helix-loop-helix protein 2; Hen; HEN-2; Hen2; NS; Nsc; Nscl-2; NSCL2
Homo sapiens (human) : NHLH2 (nescient helix-loop-helix 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nhlh2 (nescient helix loop helix 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nhlh2 (nescient helix-loop-helix 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NHLH2 (nescient helix-loop-helix 2)
Canis lupus familiaris (dog) : NHLH2 (nescient helix-loop-helix 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nhlh2 (nescient helix-loop-helix 2)
Sus scrofa (pig) : NHLH2 (nescient helix-loop-helix 2)
Chlorocebus sabaeus (African green monkey) : NHLH2 (nescient helix-loop-helix 2)
Heterocephalus glaber (naked mole-rat) : Nhlh2 (nescient helix-loop-helix 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl3102,010,076 - 102,015,492 (+)EnsemblGRCm38mm10GRCm38
GRCm383102,010,111 - 102,015,492 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373101,814,068 - 101,819,415 (+)NCBIGRCm37mm9NCBIm37
MGSCv363102,139,216 - 102,143,567 (+)NCBImm8
Celera3104,213,826 - 104,219,176 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nhlh2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1317986
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.