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Gene: NLRP3 (NLR family pyrin domain containing 3) Homo sapiens
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Symbol: NLRP3
Name: NLR family pyrin domain containing 3
Description: Exhibits identical protein binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of NIK/NF-kappaB signaling; and regulation of gene expression. Localizes to Golgi membrane and NLRP3 inflammasome complex. Implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGTAVPRL; AII; AII/AVP; AII/AVP receptor-like; angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; caterpiller protein 1.1; CIAS1; CLR1.1; cold autoinflammatory syndrome 1; cryopyrin; cryopyrin, NACHT, LRR and PYD domains - containing protein 3; deafness, autosomal dominant 34; DFNA34; FCAS; FCAS1; FCU; FLJ95925; KEFH; MWS; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NALP3; NLR family, pyrin domain containing 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1
Orthologs:
Mus musculus (house mouse) : Nlrp3 (NLR family, pyrin domain containing 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nlrp3 (NLR family, pyrin domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrp3 (NLR family pyrin domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP3 (NLR family pyrin domain containing 3)
Canis lupus familiaris (dog) : NLRP3 (NLR family pyrin domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp3 (NLR family pyrin domain containing 3)
Sus scrofa (pig) : NLRP3 (NLR family pyrin domain containing 3)
Chlorocebus sabaeus (African green monkey) : NLRP3 (NLR family pyrin domain containing 3)
Heterocephalus glaber (naked mole-rat) : Nlrp3 (NLR family pyrin domain containing 3)
more info ...
Related Pseudogenes: NLRP3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1247,416,156 - 247,449,108 (+)EnsemblGRCh38hg38GRCh38
GRCh381247,416,163 - 247,448,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371247,579,247 - 247,612,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,646,098 - 245,679,033 (+)NCBINCBI36hg18NCBI36
Build 341243,907,391 - 243,938,445NCBI
Celera1220,878,780 - 220,911,159 (+)NCBI
Cytogenetic Map1q44NCBI
HuRef1217,973,841 - 218,006,798 (+)NCBIHuRef
CHM1_11248,851,104 - 248,884,745 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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