Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nlrp3 (NLR family, pyrin domain containing 3) Mus musculus
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Description: Exhibits sequence-specific DNA binding activity and transcription factor binding activity. Involved in several processes, including cytokine production; positive regulation of macromolecule metabolic process; and response to bacterium. Localizes to NLRP3 inflammasome complex and nucleus. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-mercaptopropanoic acid; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGTAVPRL; AII/AVP; Cias1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; FCAS; FCU; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; MGC129375; Mmig1; MWS; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pypaf1; PYRIN-containing APAF1-like protein 1
Homo sapiens (human) : NLRP3 (NLR family pyrin domain containing 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nlrp3 (NLR family, pyrin domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrp3 (NLR family pyrin domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP3 (NLR family pyrin domain containing 3)
Canis lupus familiaris (dog) : NLRP3 (NLR family pyrin domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp3 (NLR family pyrin domain containing 3)
Sus scrofa (pig) : NLRP3 (NLR family pyrin domain containing 3)
Chlorocebus sabaeus (African green monkey) : NLRP3 (NLR family pyrin domain containing 3)
Heterocephalus glaber (naked mole-rat) : Nlrp3 (NLR family pyrin domain containing 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBImm8
MGSCv361159,358,881 - 59,383,151 (+)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nlrp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318015
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.