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Gene: Nlrp3 (NLR family, pyrin domain containing 3) Mus musculus
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Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Description: Exhibits sequence-specific DNA binding activity and transcription factor binding activity. Involved in several processes, including cytokine production; positive regulation of macromolecule metabolic process; and response to bacterium. Localizes to NLRP3 inflammasome complex and nucleus. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-mercaptopropanoic acid; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AGTAVPRL; AII/AVP; Cias1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; FCAS; FCU; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; MGC129375; Mmig1; MWS; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pypaf1; PYRIN-containing APAF1-like protein 1
Orthologs:
Homo sapiens (human) : NLRP3 (NLR family pyrin domain containing 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nlrp3 (NLR family, pyrin domain containing 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrp3 (NLR family pyrin domain containing 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP3 (NLR family pyrin domain containing 3)
Canis lupus familiaris (dog) : NLRP3 (NLR family pyrin domain containing 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp3 (NLR family pyrin domain containing 3)
Sus scrofa (pig) : NLRP3 (NLR family pyrin domain containing 3)
Chlorocebus sabaeus (African green monkey) : NLRP3 (NLR family pyrin domain containing 3)
Heterocephalus glaber (naked mole-rat) : Nlrp3 (NLR family pyrin domain containing 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1159,541,568 - 59,566,956 (+)EnsemblGRCm38mm10GRCm38
GRCm381159,541,569 - 59,566,955 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371159,356,188 - 59,380,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361160,078,786 - 60,103,056 (+)NCBImm8
MGSCv361159,358,881 - 59,383,151 (+)NCBImm8
Cytogenetic Map11B1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nlrp3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318015
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.