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Gene: IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon) Homo sapiens
Symbol: IKBKE
Name: inhibitor of nuclear factor kappa B kinase subunit epsilon
CRRD ID: 1318072
Description: Exhibits several functions, including K48-linked polyubiquitin modification-dependent protein binding activity; NF-kappaB-inducing kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of I-kappaB kinase/NF-kappaB signaling; and response to interferon-beta. Localizes to PML body and mitochondrial membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKE; IKKI; inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; MGC125294; MGC125295; MGC125297
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1206,470,476 - 206,496,889 (+)EnsemblGRCh38hg38GRCh38
GRCh381206,470,243 - 206,496,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371206,643,586 - 206,670,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,710,419 - 204,736,845 (+)NCBINCBI36hg18NCBI36
Build 341203,032,190 - 203,058,617NCBI
Celera1179,895,028 - 179,921,668 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1177,341,834 - 177,368,529 (+)NCBIHuRef
CHM1_11207,915,782 - 207,942,429 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IKBKE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318072
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.