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Gene: PTPA (protein phosphatase 2 phosphatase activator) Homo sapiens
Symbol: PTPA
Name: protein phosphatase 2 phosphatase activator
Description: Exhibits several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Contributes to ATPase activity. Involved in negative regulation of phosphoprotein phosphatase activity; positive regulation of apoptotic process; and positive regulation of phosphoprotein phosphatase activity. Localizes to several cellular components, including the calcium channel complex; nucleoplasm; and protein phosphatase type 2A complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC2184; phosphotyrosyl phosphatase activator; PP2A; PP2A phosphatase activator; PP2A subunit B' isoform PR53; PP2A, subunit B', PR53 isoform; PPP2R4; PR53; protein phosphatase 2A, regulatory subunit B' (PR 53); serine/threonine-protein phosphatase 2A activator; serine/threonine-protein phosphatase 2A regulatory subunit 4; serine/threonine-protein phosphatase 2A regulatory subunit B'
Mus musculus (house mouse) : Ptpa (protein phosphatase 2 protein activator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpa (protein phosphatase 2 phosphatase activator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpa (protein phosphatase 2 phosphatase activator)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPA (protein phosphatase 2 phosphatase activator)
Canis lupus familiaris (dog) : PTPA (protein phosphatase 2 phosphatase activator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpa (protein phosphatase 2 phosphatase activator)
Sus scrofa (pig) : PTPA (protein phosphatase 2 phosphatase activator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389129,110,949 - 129,148,946 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,873,183 - 131,911,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,913,065 - 130,951,044 (+)NCBINCBI36hg18NCBI36
Build 349128,953,166 - 128,990,777NCBI
Celera9102,525,511 - 102,563,513 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9101,480,193 - 101,518,132 (+)NCBIHuRef
CHM1_19132,024,045 - 132,062,045 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318076
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.