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Gene: TFAP4 (transcription factor AP-4) Homo sapiens
Symbol: TFAP4
Name: transcription factor AP-4
Description: Exhibits several functions, including E-box binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cell cycle; regulation of transcription, DNA-templated; and regulation of viral transcription. Localizes to the mitochondrion and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activating enhancer-binding protein 4; AP-4; bHLHc41; class C basic helix-loop-helix protein 41; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP-4 (activating enhancer-binding protein 4)
Mus musculus (house mouse) : Tfap4 (transcription factor AP4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfap4 (transcription factor AP-4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfap4 (transcription factor AP-4)
Pan paniscus (bonobo/pygmy chimpanzee) : TFAP4 (transcription factor AP-4)
Canis lupus familiaris (dog) : TFAP4 (transcription factor AP-4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfap4 (transcription factor AP-4)
Sus scrofa (pig) : TFAP4 (transcription factor AP-4)
Chlorocebus sabaeus (green monkey) : TFAP4 (transcription factor AP-4)
Heterocephalus glaber (naked mole-rat) : Tfap4 (transcription factor AP-4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl164,257,186 - 4,273,075 (-)Ensembl
GRCh38164,257,186 - 4,273,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37164,307,187 - 4,323,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,247,188 - 4,263,002 (-)NCBINCBI36hg18NCBI36
Build 34164,247,188 - 4,262,999NCBI
Celera164,514,186 - 4,529,994 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef164,274,201 - 4,289,950 (-)NCBIHuRef
CHM1_1164,306,776 - 4,322,587 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TFAP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318080
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.