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Gene: SH3RF2 (SH3 domain containing ring finger 2) Homo sapiens
Symbol: SH3RF2
Name: SH3 domain containing ring finger 2
CRRD ID: 1318168
Description: Exhibits protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of phosphatase activity; protein autoubiquitination; and regulation of cellular protein metabolic process. Localizes to nucleoplasm; INTERACTS WITH 5-aza-2'-deoxycytidine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase SH3RF2; FLJ23654; heart protein phosphatase 1-binding protein; HEPP1; MGC149788; MGC149789; MGC90410; POSH-eliminating RING protein; POSHER; PPP1R39; protein phosphatase 1 regulatory subunit 39; protein phosphatase 1, regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; RNF158; SH3 domain-containing RING finger protein 2
Mus musculus (house mouse) : Sh3rf2 (SH3 domain containing ring finger 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh3rf2 (SH3 domain containing ring finger 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3rf2 (SH3 domain containing ring finger 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3RF2 (SH3 domain containing ring finger 2)
Canis lupus familiaris (dog) : SH3RF2 (SH3 domain containing ring finger 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3rf2 (SH3 domain containing ring finger 2)
Sus scrofa (pig) : SH3RF2 (SH3 domain containing ring finger 2)
Chlorocebus sabaeus (African green monkey) : SH3RF2 (SH3 domain containing ring finger 2)
Heterocephalus glaber (naked mole-rat) : Sh3rf2 (SH3 domain containing ring finger 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5145,936,578 - 146,081,791 (+)EnsemblGRCh38hg38GRCh38
GRCh385145,936,570 - 146,081,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375145,316,126 - 145,458,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365145,296,335 - 145,423,048 (+)NCBINCBI36hg18NCBI36
Build 345145,296,334 - 145,423,047NCBI
Celera5141,396,292 - 141,522,973 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5140,462,976 - 140,589,659 (+)NCBIHuRef
CHM1_15144,748,936 - 144,875,627 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SH3RF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318168
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.