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Gene: RBX1 (ring-box 1) Homo sapiens
Symbol: RBX1
Name: ring-box 1
Description: Exhibits several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cellular protein metabolic process; and protein modification by small protein conjugation. Localizes to cullin-RING ubiquitin ligase complex and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BA554C12.1; E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; FLJ60363; MGC13357; MGC1481; regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; RNF75; ROC1; ZYP protein
Mus musculus (house mouse) : Rbx1 (ring-box 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rbx1 (ring-box 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rbx1 (ring-box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RBX1 (ring-box 1)
Canis lupus familiaris (dog) : RBX1 (ring-box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rbx1 (ring-box 1)
Sus scrofa (pig) : RBX1 (ring-box 1)
Chlorocebus sabaeus (African green monkey) : RBX1 (ring-box 1)
Heterocephalus glaber (naked mole-rat) : Rbx1 (ring-box 1)
more info ...
Related Pseudogenes: RBX1P1   RBX1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2240,951,347 - 40,973,309 (+)EnsemblGRCh38hg38GRCh38
GRCh382240,951,378 - 40,973,309 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,347,351 - 41,369,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,677,331 - 39,698,614 (+)NCBINCBI36hg18NCBI36
Build 342239,671,884 - 39,693,168NCBI
Celera2225,151,059 - 25,172,347 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2224,308,951 - 24,330,592 (+)NCBIHuRef
CHM1_12241,306,113 - 41,327,855 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RBX1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318229
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.