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Gene: ATP8B1 (ATPase phospholipid transporting 8B1) Homo sapiens
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Symbol: ATP8B1
Name: ATPase phospholipid transporting 8B1
Description: Predicted to have ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including negative regulation of transcription, DNA-templated; phospholipid translocation; and regulation of microvillus assembly. Localizes to several cellular components, including the Golgi apparatus; apical plasma membrane; and nuclear body. Implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, class I, type 8B, member 1; ATPIC; BRIC; E1-E2 ATPase; familial intrahepatic cholestasis type 1; FIC1; ICP1; P4-ATPase flippase complex alpha subunit ATP8B1; PFIC; PFIC1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC
Orthologs:
Mus musculus (house mouse) : Atp8b1 (ATPase, class I, type 8B, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp8b1 (ATPase phospholipid transporting 8B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp8b1 (ATPase phospholipid transporting 8B1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP8B1 (ATPase phospholipid transporting 8B1)
Canis lupus familiaris (dog) : ATP8B1 (ATPase phospholipid transporting 8B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp8b1 (ATPase phospholipid transporting 8B1)
Sus scrofa (pig) : ATP8B1 (ATPase phospholipid transporting 8B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381857,646,426 - 57,803,822 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371855,313,658 - 55,470,327 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,464,656 - 53,550,037 (-)NCBINCBI36hg18NCBI36
Build 341853,466,585 - 53,550,037NCBI
Celera1852,031,466 - 52,187,934 (-)NCBI
Cytogenetic Map18q21.31ENTREZGENE
HuRef1852,024,999 - 52,180,652 (-)NCBIHuRef
CHM1_11855,309,031 - 55,466,164 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATP8B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318284
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.