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Gene: ATP8B1 (ATPase phospholipid transporting 8B1) Homo sapiens
Symbol: ATP8B1
Name: ATPase phospholipid transporting 8B1
Description: Predicted to have ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including negative regulation of transcription, DNA-templated; phospholipid translocation; and regulation of microvillus assembly. Localizes to several cellular components, including the Golgi apparatus; apical plasma membrane; and nuclear body. Implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, class I, type 8B, member 1; ATPIC; BRIC; E1-E2 ATPase; familial intrahepatic cholestasis type 1; FIC1; ICP1; P4-ATPase flippase complex alpha subunit ATP8B1; PFIC; PFIC1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC
Mus musculus (house mouse) : Atp8b1 (ATPase, class I, type 8B, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp8b1 (ATPase phospholipid transporting 8B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp8b1 (ATPase phospholipid transporting 8B1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP8B1 (ATPase phospholipid transporting 8B1)
Canis lupus familiaris (dog) : ATP8B1 (ATPase phospholipid transporting 8B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp8b1 (ATPase phospholipid transporting 8B1)
Sus scrofa (pig) : ATP8B1 (ATPase phospholipid transporting 8B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381857,646,426 - 57,803,822 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371855,313,658 - 55,470,327 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,464,656 - 53,550,037 (-)NCBINCBI36hg18NCBI36
Build 341853,466,585 - 53,550,037NCBI
Celera1852,031,466 - 52,187,934 (-)NCBI
Cytogenetic Map18q21.31ENTREZGENE
HuRef1852,024,999 - 52,180,652 (-)NCBIHuRef
CHM1_11855,309,031 - 55,466,164 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ATP8B1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318284
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.