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Gene: Nkx2-3 (NK2 homeobox 3) Mus musculus
Symbol: Nkx2-3
Name: NK2 homeobox 3
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ morphogenesis; hematopoietic or lymphoid organ development; and post-embryonic digestive tract morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; liver; and spleen. Orthologous to human NKX2-3 (NK2 homeobox 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Drosophila NK2 transcription factor related, locus 3; homeobox protein NK-2 homolog 3; homeobox protein NK-2 homolog C; homeobox protein Nkx-2.3; NK2 transcription factor related, locus 3; Nkx-2.3; nkx2-C; Nkx2.3; tinman
Homo sapiens (human) : NKX2-3 (NK2 homeobox 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nkx2-3 (NK2 homeobox 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-3 (NK2 homeobox 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX2-3 (NK2 homeobox 3)
Canis lupus familiaris (dog) : NKX2-3 (NK2 homeobox 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-3 (NK2 homeobox 3)
Sus scrofa (pig) : NKX2-3 (NK2 homeobox 3)
Chlorocebus sabaeus (African green monkey) : NKX2-3 (NK2 homeobox 3)
Heterocephalus glaber (naked mole-rat) : Nkx2-3 (NK2 homeobox 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1943,612,325 - 43,615,892 (+)EnsemblGRCm38mm10GRCm38
GRCm381943,612,325 - 43,615,892 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371943,686,815 - 43,690,382 (+)NCBIGRCm37mm9NCBIm37
MGSCv361943,665,636 - 43,669,203 (+)NCBImm8
Celera1944,396,389 - 44,399,962 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nkx2-3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318341
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.