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Gene: CRKL (CRK like proto-oncogene, adaptor protein) Homo sapiens
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Symbol: CRKL
Name: CRK like proto-oncogene, adaptor protein
Description: Exhibits identical protein binding activity and phosphotyrosine residue binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; positive regulation of cell development; and regulation of protein phosphorylation. Localizes to the cytosol and nucleoplasm. Implicated in chronic myeloid leukemia. Biomarker of carcinoma (multiple); invasive ductal carcinoma; ovarian cancer; and skin cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
Orthologs:
Mus musculus (house mouse) : Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Crkl (CRK like proto-oncogene, adaptor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crkl (CRK like proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRKL (CRK like proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRKL (CRK like proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crkl (CRK like proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRKL (CRK like proto-oncogene, adaptor protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,917,407 - 20,953,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372221,271,714 - 21,308,037 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,601,714 - 19,637,890 (+)NCBINCBI36hg18NCBI36
Build 342219,596,267 - 19,632,443NCBI
Celera224,763,059 - 4,799,374 (+)NCBI
Cytogenetic Map22q11.21ENTREZGENE
HuRef224,539,711 - 4,576,600 (+)NCBIHuRef
CHM1_12221,271,912 - 21,308,243 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CRKL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318357
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.