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Gene: SIRT1 (sirtuin 1) Homo sapiens
Symbol: SIRT1
Name: sirtuin 1
Description: Exhibits several functions, including DNA-binding transcription factor binding activity; HLH domain binding activity; and keratin filament binding activity. Involved in several processes, including negative regulation of intracellular signal transduction; regulation of cellular protein metabolic process; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including mitochondrion; nucleus; and rDNA heterochromatin. Colocalizes with ESC/E(Z) complex. Implicated in Huntington's disease. Biomarker of several diseases, including Huntington's disease; macular degeneration; non-alcoholic fatty liver disease; prostate cancer; and senile cataract.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; regulatory protein SIR2 homolog 1; SIR2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SIR2L1; sirtuin; sirtuin type 1
Mus musculus (house mouse) : Sirt1 (sirtuin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sirt1 (sirtuin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt1 (sirtuin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT1 (sirtuin 1)
Canis lupus familiaris (dog) : SIRT1 (sirtuin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt1 (sirtuin 1)
Sus scrofa (pig) : SIRT1 (sirtuin 1)
Chlorocebus sabaeus (African green monkey) : SIRT1 (sirtuin 1)
Heterocephalus glaber (naked mole-rat) : Sirt1 (sirtuin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371069,644,427 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIRT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318374
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.