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Gene: Sirt1 (sirtuin 1) Mus musculus
Symbol: Sirt1
Name: sirtuin 1
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; NAD-dependent histone deacetylase activity (H3-K9 specific); and RNA polymerase II distal enhancer sequence-specific DNA binding activity. Involved in several processes, including lipid homeostasis; regulation of cellular biosynthetic process; and regulation of signal transduction. Localizes to the mitochondrion and nuclear heterochromatin. Predicted to colocalize with the ESC/E(Z) complex. Used to study fatty liver disease and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Is expressed in several structures, including central nervous system; exocrine gland; gonad; heart; and hemolymphoid system gland. Orthologous to human SIRT1 (sirtuin 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA673258; MGC150273; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; regulatory protein SIR2 homolog 1; Sir2; sir2-like 1; SIR2-like protein 1; Sir2a; Sir2alpha; SIR2L1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1
Homo sapiens (human) : SIRT1 (sirtuin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sirt1 (sirtuin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt1 (sirtuin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT1 (sirtuin 1)
Canis lupus familiaris (dog) : SIRT1 (sirtuin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt1 (sirtuin 1)
Sus scrofa (pig) : SIRT1 (sirtuin 1)
Chlorocebus sabaeus (green monkey) : SIRT1 (sirtuin 1)
Heterocephalus glaber (naked mole-rat) : Sirt1 (sirtuin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1063,319,005 - 63,381,704 (-)Ensembl
GRCm381063,319,005 - 63,339,035 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371062,781,753 - 62,801,783 (-)NCBIGRCm37mm9NCBIm37
MGSCv361062,714,418 - 62,734,374 (-)NCBImm8
Celera1064,419,012 - 64,437,105 (-)NCBICelera
Cytogenetic Map10B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Sirt1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318375
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.