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Gene: SHMT2 (serine hydroxymethyltransferase 2) Homo sapiens
Symbol: SHMT2
Name: serine hydroxymethyltransferase 2
Description: Exhibits chromatin binding activity; glycine hydroxymethyltransferase activity; and pyridoxal phosphate binding activity. Involved in several processes, including protein homotetramerization; regulation of generation of precursor metabolites and energy; and serine family amino acid metabolic process. Localizes to the BRISC complex; microtubule cytoskeleton; and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT; threonine aldolase
Mus musculus (house mouse) : Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial))  MGI  Alliance
Rattus norvegicus (Norway rat) : Shmt2 (serine hydroxymethyltransferase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt2 (serine hydroxymethyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT2 (serine hydroxymethyltransferase 2)
Canis lupus familiaris (dog) : SHMT2 (serine hydroxymethyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt2 (serine hydroxymethyltransferase 2)
Sus scrofa (pig) : SHMT2 (serine hydroxymethyltransferase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381257,229,685 - 57,234,935 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,623,356 - 57,628,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,909,819 - 55,914,981 (+)NCBINCBI36hg18NCBI36
Build 341255,909,818 - 55,914,981NCBI
Celera1257,277,587 - 57,282,945 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,662,237 - 54,667,595 (+)NCBIHuRef
CHM1_11257,591,454 - 57,596,816 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SHMT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318437
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.