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Gene: SHMT2 (serine hydroxymethyltransferase 2) Homo sapiens
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Symbol: SHMT2
Name: serine hydroxymethyltransferase 2
Description: Exhibits chromatin binding activity; glycine hydroxymethyltransferase activity; and pyridoxal phosphate binding activity. Involved in several processes, including protein homotetramerization; regulation of generation of precursor metabolites and energy; and serine family amino acid metabolic process. Localizes to the BRISC complex; microtubule cytoskeleton; and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT; threonine aldolase
Orthologs:
Mus musculus (house mouse) : Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial))  MGI  Alliance
Rattus norvegicus (Norway rat) : Shmt2 (serine hydroxymethyltransferase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt2 (serine hydroxymethyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT2 (serine hydroxymethyltransferase 2)
Canis lupus familiaris (dog) : SHMT2 (serine hydroxymethyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt2 (serine hydroxymethyltransferase 2)
Sus scrofa (pig) : SHMT2 (serine hydroxymethyltransferase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,229,685 - 57,234,935 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,623,356 - 57,628,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,909,819 - 55,914,981 (+)NCBINCBI36hg18NCBI36
Build 341255,909,818 - 55,914,981NCBI
Celera1257,277,587 - 57,282,945 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,662,237 - 54,667,595 (+)NCBIHuRef
CHM1_11257,591,454 - 57,596,816 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SHMT2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318437
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.