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Gene: Shmt2 (serine hydroxymethyltransferase 2 (mitochondrial)) Mus musculus
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Symbol: Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Description: Predicted to have several functions, including L-allo-threonine aldolase activity; cation binding activity; and glycine hydroxymethyltransferase activity. Involved in regulation of aerobic respiration; regulation of mitochondrial translation; and regulation of oxidative phosphorylation. Localizes to the mitochondrial inner membrane. Is expressed in several structures, including brain; neural retina; placenta; skeleton; and submandibular gland primordium. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2700043D08Rik; AA408223; AA986903; glycine hydroxymethyltransferase; serine hydroxymethyltransferase, mitochondrial; serine methylase; SHMT
Orthologs:
Homo sapiens (human) : SHMT2 (serine hydroxymethyltransferase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shmt2 (serine hydroxymethyltransferase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt2 (serine hydroxymethyltransferase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT2 (serine hydroxymethyltransferase 2)
Canis lupus familiaris (dog) : SHMT2 (serine hydroxymethyltransferase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt2 (serine hydroxymethyltransferase 2)
Sus scrofa (pig) : SHMT2 (serine hydroxymethyltransferase 2)
more info ...
Related Pseudogenes: Gm15544  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3810127,517,123 - 127,522,444 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710126,954,195 - 126,959,491 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,920,088 - 126,925,384 (-)NCBImm8
Celera10129,908,877 - 129,914,198 (-)NCBICelera
Cytogenetic Map10 D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Shmt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318438
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.