Dkk4 (dickkopf WNT signaling pathway inhibitor 4) - Chinchilla Research Resource Database
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Gene: Dkk4 (dickkopf WNT signaling pathway inhibitor 4) Mus musculus
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Symbol: Dkk4
Name: dickkopf WNT signaling pathway inhibitor 4
CRRD ID: 1318529
Description: Predicted to have co-receptor binding activity and receptor antagonist activity. Involved in Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to localize to extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dickkopf homolog 4; dickkopf-4; dickkopf-related protein 4; Dkk-4; MGC25705
Orthologs:
Homo sapiens (human) : DKK4 (dickkopf WNT signaling pathway inhibitor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dkk4 (dickkopf WNT signaling pathway inhibitor 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : DKK4 (dickkopf WNT signaling pathway inhibitor 4)
Canis lupus familiaris (dog) : DKK4 (dickkopf WNT signaling pathway inhibitor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk4 (dickkopf WNT signaling pathway inhibitor 4)
Sus scrofa (pig) : DKK4 (dickkopf WNT signaling pathway inhibitor 4)
Chlorocebus sabaeus (African green monkey) : DKK4 (dickkopf WNT signaling pathway inhibitor 4)
Heterocephalus glaber (naked mole-rat) : Dkk4 (dickkopf WNT signaling pathway inhibitor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,113,701 - 23,117,563 (+)NCBI
GRCm38822,623,685 - 22,628,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,624,043 - 22,627,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,734,515 - 23,738,019 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,089,588 - 24,093,092 (+)NCBImm8
Celera824,114,227 - 24,117,730 (+)NCBICelera
Cytogenetic Map8A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:12477932   PMID:14681479   PMID:15489334   PMID:15527894   PMID:15880404   PMID:16738056   PMID:17397822   PMID:18351675   PMID:18508042   PMID:18561327   PMID:19185060   PMID:19234195  
PMID:19387480   PMID:19619491   PMID:19806668   PMID:20386733   PMID:21087601   PMID:21267068   PMID:21531785   PMID:21873635   PMID:22115758   PMID:22277947   PMID:22434869   PMID:23108157  
PMID:23190887   PMID:23293290   PMID:23431057   PMID:23918385   PMID:24105477   PMID:24496627   PMID:25249463   PMID:26450968   PMID:26581094   PMID:26992132   PMID:27626380   PMID:27864382  
PMID:28273073   PMID:28692808   PMID:28698625   PMID:28700594   PMID:28813421   PMID:29437780   PMID:30509557   PMID:31118233  


Genomics

Comparative Map Data
Dkk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,113,701 - 23,117,563 (+)NCBI
GRCm38822,623,685 - 22,628,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,624,043 - 22,627,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,734,515 - 23,738,019 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,089,588 - 24,093,092 (+)NCBImm8
Celera824,114,227 - 24,117,730 (+)NCBICelera
Cytogenetic Map8A2NCBI
DKK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,374,063 - 42,377,229 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,373,194 - 42,391,322 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,231,586 - 42,234,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,350,743 - 42,353,831 (-)NCBINCBI36hg18NCBI36
Build 34842,350,743 - 42,353,830NCBI
Celera841,176,301 - 41,179,389 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,754,805 - 40,757,893 (-)NCBIHuRef
CHM1_1842,278,494 - 42,281,582 (-)NCBICHM1_1
Dkk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01674,260,551 - 74,264,142 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,260,551 - 74,264,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,893,385 - 73,896,976 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,888,290 - 73,891,881 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1667,295,927 - 67,299,518 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
DKK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1839,062,711 - 39,082,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,062,711 - 39,082,575 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,618,173 - 41,638,550 (-)NCBIMhudiblu_PPA_v0panPan3
DKK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1623,302,320 - 23,304,834 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11623,302,124 - 23,304,824 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dkk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936785319,494 - 323,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,390,206 - 11,394,268 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,389,551 - 11,394,754 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21712,989,140 - 12,992,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DKK4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl840,370,336 - 40,373,264 (-)Ensembl
ChlSab1.1840,370,299 - 40,386,835 (-)NCBI
Dkk4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624780873,669 - 884,091 (+)NCBI

Position Markers
Dkk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,626,885 - 22,627,442UniSTSGRCm38
MGSCv37823,737,357 - 23,737,914UniSTSGRCm37
Celera824,117,068 - 24,117,625UniSTS
Cytogenetic Map8A2UniSTS
cM Map8 UniSTS
Dkk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A2UniSTS
Dkk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,627,049 - 22,627,359UniSTSGRCm38
MGSCv37823,737,521 - 23,737,831UniSTSGRCm37
Celera824,117,232 - 24,117,542UniSTS
Cytogenetic Map8A2UniSTS
Dkk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,627,165 - 22,627,359UniSTSGRCm38
MGSCv37823,737,637 - 23,737,831UniSTSGRCm37
Celera824,117,348 - 24,117,542UniSTS
Cytogenetic Map8A2UniSTS
Dkk4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,624,234 - 22,625,357UniSTSGRCm38
MGSCv37823,734,706 - 23,735,829UniSTSGRCm37
Celera824,114,418 - 24,115,541UniSTS
Cytogenetic Map8A2UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124701082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130397432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131723288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8490000034600000Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8716249923263799Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8716249934642953Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8749417341494326Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8761318541613356Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8761318541613356Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8761318541613356Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81339721034854071Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1703261028359439Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:250
Interacting mature miRNAs:272
Transcripts:ENSMUST00000033936
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033936   ⟹   ENSMUSP00000033936
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl822,624,043 - 22,627,547 (+)Ensembl
RefSeq Acc Id: NM_145592   ⟹   NP_663567
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,114,059 - 23,117,563 (+)NCBI
GRCm38822,624,043 - 22,627,547 (+)NCBI
MGSCv37823,734,515 - 23,738,019 (+)RGD
Celera824,114,227 - 24,117,730 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509098   ⟹   XP_006509161
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,113,701 - 23,117,168 (+)NCBI
GRCm38822,623,685 - 22,628,018 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_663567 (Get FASTA)   NCBI Sequence Viewer  
  XP_006509161 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH18400 (Get FASTA)   NCBI Sequence Viewer  
  EDL32885 (Get FASTA)   NCBI Sequence Viewer  
  Q8VEJ3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_663567   ⟸   NM_145592
- Peptide Label: precursor
- UniProtKB: Q8VEJ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509161   ⟸   XM_006509098
- Peptide Label: isoform X1
- UniProtKB: Q8VEJ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033936   ⟸   ENSMUST00000033936

Promoters
RGD ID:8666683
Promoter ID:EPDNEW_M11373
Type:single initiation site
Name:Dkk4_1
Description:Mus musculus dickkopf WNT signaling pathway inhibitor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38822,624,022 - 22,624,082EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385299 AgrOrtholog
Ensembl Genes ENSMUSG00000031535 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000033936 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033936 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Dickkopf_N UniProtKB/Swiss-Prot
  DKK-like UniProtKB/Swiss-Prot
  Prokineticin_domain UniProtKB/Swiss-Prot
KEGG Report mmu:234130 UniProtKB/Swiss-Prot
MGD MGI:2385299 ENTREZGENE
NCBI Gene 234130 ENTREZGENE
PANTHER PTHR12113 UniProtKB/Swiss-Prot
Pfam Dickkopf_N UniProtKB/Swiss-Prot
  Prokineticin UniProtKB/Swiss-Prot
PhenoGen Dkk4 PhenoGen
UniGene Mm.157322 ENTREZGENE
UniProt DKK4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Dkk4  dickkopf WNT signaling pathway inhibitor 4    dickkopf homolog 4 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED