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Gene: Stk11 (serine/threonine kinase 11) Mus musculus
Symbol: Stk11
Name: serine/threonine kinase 11
Description: Exhibits LRR domain binding activity; protein kinase activator activity; and protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; positive regulation of protein phosphorylation; and regulation of signal transduction. Localizes to several cellular components, including the TCR signalosome; cytosol; and nucleus. Used to study Peutz-Jeghers syndrome and endometrial cancer. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; ovarian carcinoma; and pancreatic cancer. Is expressed in several structures, including alimentary system; blood; genitourinary system; lung; and nervous system. Orthologous to human STK11 (serine/threonine kinase 11).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408040; liver kinase B1 homolog; Lkb1; LKB1 short isoform; mLKB1; Par-4; R75140; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
Homo sapiens (human) : STK11 (serine/threonine kinase 11)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Stk11 (serine/threonine kinase 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stk11 (serine/threonine kinase 11)
Pan paniscus (bonobo/pygmy chimpanzee) : STK11 (serine/threonine kinase 11)
Canis lupus familiaris (dog) : STK11 (serine/threonine kinase 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stk11 (serine/threonine kinase 11)
Sus scrofa (pig) : STK11 (serine/threonine kinase 11)
Chlorocebus sabaeus (African green monkey) : STK11 (serine/threonine kinase 11)
Heterocephalus glaber (naked mole-rat) : Stk11 (serine/threonine kinase 11)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1080,115,803 - 80,130,682 (+)Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBImm8
Celera1081,130,635 - 81,145,517 (+)NCBICelera
Cytogenetic Map10C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Stk11
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318549
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.