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Gene: Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) Mus musculus
Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Description: Predicted to have 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; hippocampus development; and response to corticosterone. Localizes to mitochondrion. Is expressed in several structures, including endocrine gland; genitourinary system; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; D3Ertd383; D3Ertd383e; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; steroid Delta-isomerase
Related Pseudogenes: Gm12399  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl398,852,194 - 98,859,794 (-)EnsemblGRCm38mm10GRCm38
GRCm38398,842,356 - 98,859,794 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37398,656,120 - 98,663,717 (-)NCBIGRCm37mm9NCBIm37
MGSCv36398,981,255 - 98,987,280 (-)NCBImm8
Celera3100,188,018 - 100,195,618 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hsd3b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318589
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.