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Gene: SPRED1 (sprouty related EVH1 domain containing 1) Homo sapiens
Symbol: SPRED1
Name: sprouty related EVH1 domain containing 1
Description: Exhibits phosphatase binding activity and protein kinase binding activity. Involved in negative regulation of angiogenesis; negative regulation of phosphate metabolic process; and vasculogenesis involved in coronary vascular morphogenesis. Localizes to the cytosol and nucleoplasm. Colocalizes with the cytoplasmic vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EVH1/Sprouty domain containing protein; FLJ33903; hSpred1; LGSS; NFLS; PPP1R147; spred-1; sprouty related, EVH1 domain containing 1; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Mus musculus (house mouse) : Spred1 (sprouty protein with EVH-1 domain 1, related sequence)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spred1 (sprouty-related, EVH1 domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spred1 (sprouty related EVH1 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRED1 (sprouty related EVH1 domain containing 1)
Canis lupus familiaris (dog) : SPRED1 (sprouty related EVH1 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spred1 (sprouty related EVH1 domain containing 1)
Sus scrofa (pig) : SPRED1 (sprouty related EVH1 domain containing 1)
Chlorocebus sabaeus (African green monkey) : SPRED1 (sprouty related EVH1 domain containing 1)
Heterocephalus glaber (naked mole-rat) : Spred1 (sprouty related EVH1 domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1538,252,836 - 38,357,249 (+)EnsemblGRCh38hg38GRCh38
GRCh381538,252,087 - 38,357,249 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371538,544,925 - 38,649,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361536,331,808 - 36,433,533 (+)NCBINCBI36hg18NCBI36
Build 341536,331,807 - 36,433,533NCBI
Celera1515,312,281 - 15,416,681 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1515,389,475 - 15,493,873 (+)NCBIHuRef
CHM1_11538,664,324 - 38,768,708 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPRED1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318683
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.