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Gene: XPA (XPA, DNA damage recognition and repair factor) Homo sapiens
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Symbol: XPA
Name: XPA, DNA damage recognition and repair factor
Description: Exhibits damaged DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Involved in UV protection; nucleotide-excision repair, DNA incision; and protein localization to nucleus. Localizes to the intercellular bridge and nucleoplasm. Colocalizes with the DNA replication factor A complex. Implicated in xeroderma pigmentosum and xeroderma pigmentosum group A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; RP11-244N9.4; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
Orthologs:
Mus musculus (house mouse) : Xpa (xeroderma pigmentosum, complementation group A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xpa (XPA, DNA damage recognition and repair factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xpa (XPA, DNA damage recognition and repair factor)
Pan paniscus (bonobo/pygmy chimpanzee) : XPA (XPA, DNA damage recognition and repair factor)
Canis lupus familiaris (dog) : XPA (XPA, DNA damage recognition and repair factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xpa (XPA, DNA damage recognition and repair factor)
Sus scrofa (pig) : XPA (XPA, DNA damage recognition and repair factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38997,654,398 - 97,697,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379100,437,191 - 100,459,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36999,477,012 - 99,499,512 (-)NCBINCBI36hg18NCBI36
Build 34997,516,746 - 97,539,194NCBI
Celera970,951,417 - 70,973,928 (-)NCBI
Cytogenetic Map9q22.33NCBI
HuRef970,038,231 - 70,060,725 (-)NCBIHuRef
CHM1_19100,583,626 - 100,606,139 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on XPA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318735
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.