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Gene: XPA (XPA, DNA damage recognition and repair factor) Homo sapiens
Symbol: XPA
Name: XPA, DNA damage recognition and repair factor
Description: Exhibits damaged DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Involved in UV protection; nucleotide-excision repair, DNA incision; and protein localization to nucleus. Localizes to the intercellular bridge and nucleoplasm. Colocalizes with the DNA replication factor A complex. Implicated in xeroderma pigmentosum and xeroderma pigmentosum group A.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; RP11-244N9.4; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
Mus musculus (house mouse) : Xpa (xeroderma pigmentosum, complementation group A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xpa (XPA, DNA damage recognition and repair factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xpa (XPA, DNA damage recognition and repair factor)
Pan paniscus (bonobo/pygmy chimpanzee) : XPA (XPA, DNA damage recognition and repair factor)
Canis lupus familiaris (dog) : XPA (XPA, DNA damage recognition and repair factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xpa (XPA, DNA damage recognition and repair factor)
Sus scrofa (pig) : XPA (XPA, DNA damage recognition and repair factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38997,654,398 - 97,697,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379100,437,191 - 100,459,691 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36999,477,012 - 99,499,512 (-)NCBINCBI36hg18NCBI36
Build 34997,516,746 - 97,539,194NCBI
Celera970,951,417 - 70,973,928 (-)NCBI
Cytogenetic Map9q22.33NCBI
HuRef970,038,231 - 70,060,725 (-)NCBIHuRef
CHM1_19100,583,626 - 100,606,139 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XPA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318735
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.