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Gene: Xpa (xeroderma pigmentosum, complementation group A) Mus musculus
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Symbol: Xpa
Name: xeroderma pigmentosum, complementation group A
Description: Predicted to have damaged DNA binding activity; protein domain specific binding activity; and protein homodimerization activity. Involved in several processes, including growth; intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of transcription initiation from RNA polymerase II promoter. Localizes to the nucleus. Predicted to colocalize with the DNA replication factor A complex. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Is expressed in forelimb bud. Orthologous to human XPA (XPA, DNA damage recognition and repair factor); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI573865; DNA repair protein complementing XP-A cells homolog; xeroderma pigmentosum group A-complementing protein homolog; Xpac
Orthologs:
Homo sapiens (human) : XPA (XPA, DNA damage recognition and repair factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xpa (XPA, DNA damage recognition and repair factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xpa (XPA, DNA damage recognition and repair factor)
Pan paniscus (bonobo/pygmy chimpanzee) : XPA (XPA, DNA damage recognition and repair factor)
Canis lupus familiaris (dog) : XPA (XPA, DNA damage recognition and repair factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xpa (XPA, DNA damage recognition and repair factor)
Sus scrofa (pig) : XPA (XPA, DNA damage recognition and repair factor)
Chlorocebus sabaeus (green monkey) : XPA (XPA, DNA damage recognition and repair factor)
Heterocephalus glaber (naked mole-rat) : Xpa (XPA, DNA damage recognition and repair factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl446,155,347 - 46,196,311 (-)Ensembl
GRCm38446,175,220 - 46,196,344 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37446,188,094 - 46,209,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv36446,196,339 - 46,217,411 (-)NCBImm8
Celera446,197,357 - 46,218,441 (-)NCBICelera
Cytogenetic Map4 B1NCBI
cM Map424.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Xpa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318736
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.