Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: USP3 (ubiquitin specific peptidase 3) Homo sapiens
Symbol: USP3
Name: ubiquitin specific peptidase 3
Description: Exhibits histone binding activity and thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Localizes to Flemming body; cytoplasmic ribonucleoprotein granule; and nuclear lumen; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: deubiquitinating enzyme 3; MGC129878; MGC129879; SIH003; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin specific protease 3; ubiquitin thioesterase 3; ubiquitin thiolesterase 3; ubiquitin-specific-processing protease 3; UBP
Mus musculus (house mouse) : Usp3 (ubiquitin specific peptidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp3 (ubiquitin specific peptidase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp3 (ubiquitin specific peptidase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : USP3 (ubiquitin specific peptidase 3)
Canis lupus familiaris (dog) : USP3 (ubiquitin specific peptidase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp3 (ubiquitin specific peptidase 3)
Sus scrofa (pig) : USP3 (ubiquitin specific peptidase 3)
Chlorocebus sabaeus (African green monkey) : USP3 (ubiquitin specific peptidase 3)
Heterocephalus glaber (naked mole-rat) : Usp3 (ubiquitin specific peptidase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1563,504,511 - 63,594,640 (+)EnsemblGRCh38hg38GRCh38
GRCh381563,504,511 - 63,594,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371563,796,710 - 63,886,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,583,863 - 61,670,716 (+)NCBINCBI36hg18NCBI36
Build 341561,583,862 - 61,670,714NCBI
Celera1540,676,343 - 40,763,066 (+)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1540,621,287 - 40,711,268 (+)NCBIHuRef
CHM1_11563,915,941 - 64,006,065 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on USP3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318862
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.