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Gene: Lama2 (laminin, alpha 2) Mus musculus
Symbol: Lama2
Name: laminin, alpha 2
Description: Predicted to have extracellular matrix structural constituent and signaling receptor binding activity. Involved in axon guidance and positive regulation of cholinergic synaptic transmission. Localizes to several cellular components, including the neuromuscular junction; sarcolemma; and synaptic cleft. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Is expressed in several structures, including alimentary system; metanephros; musculature; nervous system; and skin. Orthologous to human LAMA2 (laminin subunit alpha 2); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5830440B04; dy; dystrophia muscularis; KIAA4087; laminin M chain; laminin subunit alpha-2; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; mer; merosin; merosin heavy chain; mKIAA4087
Homo sapiens (human) : LAMA2 (laminin subunit alpha 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lama2 (laminin subunit alpha 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lama2 (laminin subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMA2 (laminin subunit alpha 2)
Canis lupus familiaris (dog) : LAMA2 (laminin subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lama2 (laminin subunit alpha 2)
Sus scrofa (pig) : LAMA2 (laminin subunit alpha 2)
Chlorocebus sabaeus (African green monkey) : LAMA2 (laminin subunit alpha 2)
Heterocephalus glaber (naked mole-rat) : Lama2 (laminin subunit alpha 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1026,980,036 - 27,619,758 (-)Ensembl
GRCm381026,981,285 - 27,617,191 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371026,701,091 - 27,336,748 (-)NCBIGRCm37mm9NCBIm37
MGSCv361026,670,819 - 27,306,267 (-)NCBImm8
Celera1027,907,208 - 28,541,586 (-)NCBICelera
Cytogenetic Map10 A4NCBI
cM Map1014.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lama2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318919
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.