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Gene: Large1 (LARGE xylosyl- and glucuronyltransferase 1) Mus musculus
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Symbol: Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
CRRD ID: 1318928
Description: Exhibits glucuronosyltransferase activity and xylosyltransferase activity. Involved in several processes, including muscle cell cellular homeostasis; protein O-linked mannosylation; and skeletal muscle organ development. Localizes to intracellular membrane-bounded organelle. Is expressed in nervous system and retina. Used to study facioscapulohumeral muscular dystrophy; muscular dystrophy-dystroglycanopathy; and muscular dystrophy-dystroglycanopathy type B6. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetylglucosaminyltransferase-like 1A; BPFD#3; BPFD#36; e; enr; fg; frog; froggy; glycosyltransferase-like protein LARGE1; Gyltl1a; Large; like-glycosyltransferase; Mbp-1; Mbp1; mKIAA0609; myd; myodystrophy
Orthologs:
Homo sapiens (human) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Canis lupus familiaris (dog) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
Sus scrofa (pig) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Chlorocebus sabaeus (African green monkey) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,541,226 - 74,080,279 (-)NCBI
GRCm38872,814,598 - 73,353,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv37875,338,498 - 75,876,455 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,710,671 - 76,248,628 (-)NCBImm8
Celera877,131,292 - 77,664,765 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map835.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Large1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318928
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.