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Gene: Nprl2 (NPR2 like, GATOR1 complex subunit) Mus musculus
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Symbol: Nprl2
Name: NPR2 like, GATOR1 complex subunit
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to starvation; negative regulation of TOR signaling; and regulation of autophagy. Predicted to localize to GATOR1 complex and lysosomal membrane. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810446G01Rik; G21; GATOR complex protein NPRL2; gene 21 protein; nitrogen permase homolog; nitrogen permease regulator 2-like protein; nitrogen permease regulator-like 2; NPR2-like protein; NPR2L; tumor suppressor candidate 4; Tusc4
Orthologs:
Homo sapiens (human) : NPRL2 (NPR2 like, GATOR1 complex subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nprl2 (NPR2-like, GATOR1 complex subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nprl2 (NPR2 like, GATOR1 complex subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Canis lupus familiaris (dog) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nprl2 (NPR2 like, GATOR1 complex subunit)
Sus scrofa (pig) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Chlorocebus sabaeus (African green monkey) : NPRL2 (NPR2 like, GATOR1 complex subunit)
Heterocephalus glaber (naked mole-rat) : Nprl2 (NPR2 like, GATOR1 complex subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl9107,542,226 - 107,545,706 (+)EnsemblGRCm38mm10GRCm38
GRCm389107,542,177 - 107,545,706 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379107,444,540 - 107,448,037 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,400,327 - 107,403,796 (+)NCBImm8
Celera9107,150,974 - 107,154,469 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Nprl2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1318979
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.