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Gene: MELK (maternal embryonic leucine zipper kinase) Homo sapiens
Symbol: MELK
Name: maternal embryonic leucine zipper kinase
Description: Exhibits calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Localizes to the cell cortex and plasma membrane; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hMELK; HPK38; KIAA0175; pEg3 kinase; protein kinase Eg3; protein kinase PK38; tyrosine-protein kinase MELK
Mus musculus (house mouse) : Melk (maternal embryonic leucine zipper kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Melk (maternal embryonic leucine zipper kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Melk (maternal embryonic leucine zipper kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MELK (maternal embryonic leucine zipper kinase)
Canis lupus familiaris (dog) : MELK (maternal embryonic leucine zipper kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Melk (maternal embryonic leucine zipper kinase)
Sus scrofa (pig) : MELK (maternal embryonic leucine zipper kinase)
Chlorocebus sabaeus (green monkey) : MELK (maternal embryonic leucine zipper kinase)
Heterocephalus glaber (naked mole-rat) : Melk (maternal embryonic leucine zipper kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl936,572,862 - 36,677,683 (+)Ensembl
GRCh38936,572,862 - 36,677,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37936,572,859 - 36,677,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,562,905 - 36,667,679 (+)NCBINCBI36hg18NCBI36
Build 34936,562,904 - 36,667,678NCBI
Celera936,506,192 - 36,610,971 (+)NCBI
Cytogenetic Map9p13.2NCBI
HuRef936,525,297 - 36,629,824 (+)NCBIHuRef
CHM1_1936,573,419 - 36,678,272 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MELK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319059
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.