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Gene: Melk (maternal embryonic leucine zipper kinase) Mus musculus
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Symbol: Melk
Name: maternal embryonic leucine zipper kinase
Description: Exhibits protein serine/threonine kinase activity. Involved in intrinsic apoptotic signaling pathway in response to oxidative stress; neural precursor cell proliferation; and positive regulation of apoptotic process. Localizes to cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AI327312; mKIAA0175; MPK38; protein kinase PK38; tyrosine-protein kinase MELK
Orthologs:
Homo sapiens (human) : MELK (maternal embryonic leucine zipper kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Melk (maternal embryonic leucine zipper kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Melk (maternal embryonic leucine zipper kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MELK (maternal embryonic leucine zipper kinase)
Canis lupus familiaris (dog) : MELK (maternal embryonic leucine zipper kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Melk (maternal embryonic leucine zipper kinase)
Sus scrofa (pig) : MELK (maternal embryonic leucine zipper kinase)
Chlorocebus sabaeus (African green monkey) : MELK (maternal embryonic leucine zipper kinase)
Heterocephalus glaber (naked mole-rat) : Melk (maternal embryonic leucine zipper kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl444,300,876 - 44,364,675 (+)EnsemblGRCm38mm10GRCm38
GRCm38444,300,909 - 44,364,675 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37444,313,789 - 44,377,547 (+)NCBIGRCm37mm9NCBIm37
MGSCv36444,322,017 - 44,385,775 (+)NCBImm8
Celera444,320,472 - 44,384,714 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Melk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319060
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.