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Gene: NGEF (neuronal guanine nucleotide exchange factor) Homo sapiens
Symbol: NGEF
Name: neuronal guanine nucleotide exchange factor
Description: Exhibits guanyl-nucleotide exchange factor activity. Predicted to be involved in ephrin receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and regulation of GTPase activity. Predicted to localize to the cytosol; PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 8-bromo-3',5'-cyclic AMP; aflatoxin B1; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ARHGEF27; eph-interacting exchange protein; ephexin; ephexin-1; ephexin1
Mus musculus (house mouse) : Ngef (neuronal guanine nucleotide exchange factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ngef (neuronal guanine nucleotide exchange factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngef (neuronal guanine nucleotide exchange factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGEF (neuronal guanine nucleotide exchange factor)
Canis lupus familiaris (dog) : NGEF (neuronal guanine nucleotide exchange factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngef (neuronal guanine nucleotide exchange factor)
Sus scrofa (pig) : NGEF (neuronal guanine nucleotide exchange factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2232,878,701 - 233,013,256 (-)Ensembl
GRCh382232,878,686 - 233,013,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372233,743,396 - 233,877,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,451,655 - 233,586,182 (-)NCBINCBI36hg18NCBI36
Celera2227,507,672 - 227,643,202 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2225,592,253 - 225,726,431 (-)NCBIHuRef
CHM1_12233,749,324 - 233,883,758 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NGEF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319181
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.