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Gene: CYLD (CYLD lysine 63 deubiquitinase) Homo sapiens
Symbol: CYLD
Name: CYLD lysine 63 deubiquitinase
CRRD ID: 1319183
Description: Exhibits several functions, including proline-rich region binding activity; ubiquitinyl hydrolase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein deubiquitination; and regulation of signal transduction. Localizes to cytosol; extrinsic component of cytoplasmic side of plasma membrane; and microtubule cytoskeleton. Colocalizes with cytoplasmic microtubule and midbody. Implicated in Brooke-Spiegler syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRSS; CDMT; CYLD1; CYLDI; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; EAC; FLJ20180; FLJ31664; FLJ78684; HSPC057; KIAA0849; MFT; MFT1; probable ubiquitin carboxyl-terminal hydrolase CYLD; SBS; TEM; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD; USPL2
Mus musculus (house mouse) : Cyld (CYLD lysine 63 deubiquitinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyld (CYLD lysine 63 deubiquitinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cyld (CYLD lysine 63 deubiquitinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYLD (CYLD lysine 63 deubiquitinase)
Canis lupus familiaris (dog) : CYLD (CYLD lysine 63 deubiquitinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyld (CYLD lysine 63 deubiquitinase)
Sus scrofa (pig) : CYLD (CYLD lysine 63 deubiquitinase)
Chlorocebus sabaeus (African green monkey) : CYLD (CYLD lysine 63 deubiquitinase)
Heterocephalus glaber (naked mole-rat) : Cyld (CYLD lysine 63 deubiquitinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1650,742,050 - 50,801,935 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,742,086 - 50,801,935 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,775,961 - 50,835,847 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,333,462 - 49,393,347 (+)NCBINCBI36hg18NCBI36
Build 341649,333,485 - 49,390,029NCBI
Celera1635,291,289 - 35,351,164 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,663,187 - 36,723,275 (+)NCBIHuRef
CHM1_11652,183,487 - 52,243,322 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYLD
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319183
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.