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Gene: Cyld (CYLD lysine 63 deubiquitinase) Mus musculus
Symbol: Cyld
Name: CYLD lysine 63 deubiquitinase
CRRD ID: 1319184
Description: Exhibits Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including protein deubiquitination; regulation of lymphocyte differentiation; and regulation of signal transduction. Localizes to ciliary basal body and ciliary tip. Predicted to colocalize with cytoplasmic microtubule and midbody. Is expressed in several structures, including alimentary system; lower urinary tract; nose; pituitary gland; and skin. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; EAC; mKIAA0849; probable ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD
Homo sapiens (human) : CYLD (CYLD lysine 63 deubiquitinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyld (CYLD lysine 63 deubiquitinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cyld (CYLD lysine 63 deubiquitinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYLD (CYLD lysine 63 deubiquitinase)
Canis lupus familiaris (dog) : CYLD (CYLD lysine 63 deubiquitinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyld (CYLD lysine 63 deubiquitinase)
Sus scrofa (pig) : CYLD (CYLD lysine 63 deubiquitinase)
Chlorocebus sabaeus (African green monkey) : CYLD (CYLD lysine 63 deubiquitinase)
Heterocephalus glaber (naked mole-rat) : Cyld (CYLD lysine 63 deubiquitinase)
more info ...
Related Pseudogenes: Gm6679  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39889,423,506 - 89,478,574 (+)NCBI
GRCm38888,696,878 - 88,751,946 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,697,028 - 88,751,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,220,927 - 91,275,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,587,180 - 91,638,560 (+)NCBImm8
Celera892,977,380 - 93,032,328 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Cyld
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319184
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.