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Gene: Cyld (CYLD lysine 63 deubiquitinase) Mus musculus
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Symbol: Cyld
Name: CYLD lysine 63 deubiquitinase
CRRD ID: 1319184
Description: Exhibits Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including protein deubiquitination; regulation of lymphocyte differentiation; and regulation of signal transduction. Localizes to ciliary basal body and ciliary tip. Predicted to colocalize with cytoplasmic microtubule and midbody. Is expressed in several structures, including alimentary system; lower urinary tract; nose; pituitary gland; and skin. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; EAC; mKIAA0849; probable ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD
Orthologs:
Homo sapiens (human) : CYLD (CYLD lysine 63 deubiquitinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyld (CYLD lysine 63 deubiquitinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cyld (CYLD lysine 63 deubiquitinase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYLD (CYLD lysine 63 deubiquitinase)
Canis lupus familiaris (dog) : CYLD (CYLD lysine 63 deubiquitinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyld (CYLD lysine 63 deubiquitinase)
Sus scrofa (pig) : CYLD (CYLD lysine 63 deubiquitinase)
Chlorocebus sabaeus (African green monkey) : CYLD (CYLD lysine 63 deubiquitinase)
Heterocephalus glaber (naked mole-rat) : Cyld (CYLD lysine 63 deubiquitinase)
more info ...
Related Pseudogenes: Gm6679  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,423,506 - 89,478,574 (+)NCBI
GRCm38888,696,878 - 88,751,946 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,697,028 - 88,751,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,220,927 - 91,275,844 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,587,180 - 91,638,560 (+)NCBImm8
Celera892,977,380 - 93,032,328 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Cyld
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319184
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.