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Gene: C1R (complement C1r) Homo sapiens
Symbol: C1R
Name: complement C1r
Description: Exhibits calcium ion binding activity and serine-type endopeptidase activity. Involved in zymogen activation. Localizes to the extracellular space. Implicated in Ehlers-Danlos syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: complement C1r subcomponent; complement component 1 subcomponent r; complement component 1, r subcomponent; EDSPD1
Mus musculus (house mouse) : C1rb (complement component 1, r subcomponent B)  MGI  Alliance
Rattus norvegicus (Norway rat) : C1r (complement C1r)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C1r (complement C1r)
Pan paniscus (bonobo/pygmy chimpanzee) : C1R (complement C1r)
Canis lupus familiaris (dog) : C1R (complement C1r)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C1r (complement C1r)
Sus scrofa (pig) : C1R (complement C1r)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38127,080,219 - 7,092,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,241,205 - 7,245,043 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37127,187,513 - 7,189,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,057,768 - 7,058,863 (-)NCBINCBI36hg18NCBI36
Build 36127,132,347 - 7,136,184 (-)NCBINCBI36hg18NCBI36
Build 34127,132,345 - 7,136,184NCBI
Celera128,810,415 - 8,821,122 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef127,047,821 - 7,049,720 (-)NCBIHuRef
HuRef127,051,362 - 7,057,949 (-)NCBIHuRef
CHM1_1127,186,493 - 7,244,018 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on C1R
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319235
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.