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Gene: RIPK2 (receptor interacting serine/threonine kinase 2) Homo sapiens
Symbol: RIPK2
Name: receptor interacting serine/threonine kinase 2
CRRD ID: 1319357
Description: Exhibits several functions, including caspase binding activity; protein domain specific binding activity; and protein homodimerization activity. Involved in several processes, including pattern recognition receptor signaling pathway; positive regulation of cellular protein metabolic process; and regulation of gene expression. Localizes to several cellular components, including cytoskeleton; cytosol; and vesicle.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; tyrosine-protein kinase RIPK2
Mus musculus (house mouse) : Ripk2 (receptor (TNFRSF)-interacting serine-threonine kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ripk2 (receptor-interacting serine-threonine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ripk2 (receptor interacting serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RIPK2 (receptor interacting serine/threonine kinase 2)
Canis lupus familiaris (dog) : RIPK2 (receptor interacting serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ripk2 (receptor interacting serine/threonine kinase 2)
Sus scrofa (pig) : RIPK2 (receptor interacting serine/threonine kinase 2)
Chlorocebus sabaeus (African green monkey) : RIPK2 (receptor interacting serine/threonine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ripk2 (receptor interacting serine/threonine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl889,757,806 - 89,791,064 (+)EnsemblGRCh38hg38GRCh38
GRCh38889,757,816 - 89,791,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37890,769,335 - 90,803,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36890,839,110 - 90,872,433 (+)NCBINCBI36hg18NCBI36
Build 34890,839,172 - 90,872,432NCBI
Celera886,964,831 - 86,998,139 (+)NCBI
Cytogenetic Map8q21.3NCBI
HuRef885,980,380 - 86,013,697 (+)NCBIHuRef
CHM1_1890,811,006 - 90,844,310 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RIPK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319357
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.