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Gene: Shc4 (SHC (Src homology 2 domain containing) family, member 4) Mus musculus
Symbol: Shc4
Name: SHC (Src homology 2 domain containing) family, member 4
Description: Exhibits protein domain specific binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to localize to the plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and skin. Orthologous to human SHC4 (SHC adaptor protein 4); PARTICIPATES IN chronic myeloid leukemia pathway; epidermal growth factor/neuregulin signaling pathway; glioma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6230417E10Rik; 9930029B02Rik; Gm685; mShcD; novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein; rai-like protein RaLP; RaLP; RP23-323D9.1; SH2 domain protein C4; SHC-transforming protein 4; SHC-transforming protein D; src homology 2 domain-containing-transforming protein C4
Homo sapiens (human) : SHC4 (SHC adaptor protein 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shc4 (SHC adaptor protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shc4 (SHC adaptor protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SHC4 (SHC adaptor protein 4)
Canis lupus familiaris (dog) : SHC4 (SHC adaptor protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shc4 (SHC adaptor protein 4)
Sus scrofa (pig) : SHC4 (SHC adaptor protein 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382125,627,439 - 125,724,148 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372125,453,183 - 125,549,884 (-)NCBIGRCm37mm9NCBIm37
MGSCv362125,318,888 - 125,415,589 (-)NCBImm8
Celera2126,873,463 - 126,969,748 (-)NCBICelera
Cytogenetic Map2 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Shc4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319380
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.