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Gene: ZFHX3 (zinc finger homeobox 3) Homo sapiens
Symbol: ZFHX3
Name: zinc finger homeobox 3
Description: Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity and enzyme binding activity. Involved in regulation of myoblast differentiation; regulation of transcription, DNA-templated; and response to transforming growth factor beta. Localizes to the cytoplasm; nuclear body; and transcription factor complex. Implicated in prostate cancer. Biomarker of breast carcinoma and cervical cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-fetoprotein enhancer binding protein; alpha-fetoprotein enhancer-binding protein; AT motif-binding factor 1; AT-binding transcription factor 1; ATBF1; ATBT; C16orf47; chromosome 16 open reading frame 47; putative uncharacterized protein C16orf47; ZFH-3; zinc finger homeobox protein 3; zinc finger homeodomain protein 3; ZNF927
Mus musculus (house mouse) : Zfhx3 (zinc finger homeobox 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zfhx3 (zinc finger homeobox 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zfhx3 (zinc finger homeobox 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ZFHX3 (zinc finger homeobox 3)
Canis lupus familiaris (dog) : ZFHX3 (zinc finger homeobox 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zfhx3 (zinc finger homeobox 3)
Sus scrofa (pig) : ZFHX3 (zinc finger homeobox 3)
Chlorocebus sabaeus (African green monkey) : ZFHX3 (zinc finger homeobox 3)
Heterocephalus glaber (naked mole-rat) : Zfhx3 (zinc finger homeobox 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1672,782,885 - 73,891,871 (-)Ensembl
GRCh381672,782,885 - 73,891,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371672,816,784 - 73,092,534 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361671,374,285 - 71,639,775 (-)NCBINCBI36hg18NCBI36
Build 341671,378,455 - 71,639,775NCBI
Celera1657,132,611 - 57,398,274 (-)NCBI
Cytogenetic Map16q22.2-q22.3NCBI
HuRef1658,584,915 - 58,866,797 (-)NCBIHuRef
CHM1_11674,229,746 - 74,505,362 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZFHX3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319399
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.