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Gene: MALT1 (MALT1 paracaspase) Homo sapiens
Symbol: MALT1
Name: MALT1 paracaspase
Description: Exhibits several functions, including identical protein binding activity; protein self-association; and ubiquitin-protein transferase activity. Contributes to kinase activator activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Localizes to CBM complex; cytosol; and fibrillar center. Implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: caspase-like protein; DKFZp434L132; IMD12; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MALT1 protease; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; paracaspase 1; paracaspase-1; PCASP1
Mus musculus (house mouse) : Malt1 (MALT1 paracaspase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Malt1 (MALT1 paracaspase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Malt1 (MALT1 paracaspase)
Pan paniscus (bonobo/pygmy chimpanzee) : MALT1 (MALT1 paracaspase)
Canis lupus familiaris (dog) : MALT1 (MALT1 paracaspase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Malt1 (MALT1 paracaspase)
Sus scrofa (pig) : MALT1 (MALT1 paracaspase)
Chlorocebus sabaeus (African green monkey) : MALT1 (MALT1 paracaspase)
Heterocephalus glaber (naked mole-rat) : Malt1 (MALT1 paracaspase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1858,671,465 - 58,754,477 (+)EnsemblGRCh38hg38GRCh38
GRCh381858,671,420 - 58,754,477 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371856,338,618 - 56,417,371 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,489,598 - 54,568,350 (+)NCBINCBI36hg18NCBI36
Build 341854,489,597 - 54,568,350NCBI
Celera1853,055,193 - 53,133,688 (+)NCBI
Cytogenetic Map18q21.32NCBI
HuRef1853,046,774 - 53,125,499 (+)NCBIHuRef
CHM1_11856,333,855 - 56,412,584 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MALT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319401
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.