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Gene: FOXO3 (forkhead box O3) Homo sapiens
Symbol: FOXO3
Name: forkhead box O3
Description: Exhibits several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of erythrocyte differentiation; regulation of cellular macromolecule biosynthetic process; and tumor necrosis factor-mediated signaling pathway. Localizes to several cellular components, including the cytosol; mitochondrial outer membrane; and nucleoplasm. Colocalizes with the mitochondrial matrix. Biomarker of Alzheimer's disease; endometrial adenocarcinoma; prostate cancer; rheumatoid arthritis; and temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF6q21; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3A; forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3A; MGC12739; MGC31925
Mus musculus (house mouse) : Foxo3 (forkhead box O3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxo3 (forkhead box O3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo3 (forkhead box O3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO3 (forkhead box O3)
Canis lupus familiaris (dog) : FOXO3 (forkhead box O3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo3 (forkhead box O3)
Sus scrofa (pig) : FOXO3 (forkhead box O3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6108,559,835 - 108,684,774 (+)Ensembl
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376108,881,026 - 109,005,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FOXO3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319403
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.