Gene: Cir1 (corepressor interacting with RBPJ, 1) Mus musculus
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Symbol:
Cir1
Name:
corepressor interacting with RBPJ, 1
Description:
Predicted to have histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Involved in in utero embryonic development. Predicted to colocalize with the centrosome. Is expressed in genitourinary system and limb ectoderm. Orthologous to human CIR1 (corepressor interacting with RBPJ, 1); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH bisphenol A; amphetamine (ortholog); cadmium dichloride (ortholog).
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1700023B02Rik; 2810021A19Rik; CBF1 interacting corepressor; CBF1-interacting corepressor; Cicr; Cir; corepressor interacting with RBPJ 1; MGC117636; RP23-463K8.2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CIR1 (corepressor interacting with RBPJ, 1)
HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cir1 (corepressor interacting with RBPJ, 1)
HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cir1 (corepressor interacting with RBPJ, 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CIR1 (corepressor interacting with RBPJ, 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CIR1 (corepressor interacting with RBPJ, 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cir1 (corepressor interacting with RBPJ, 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CIR1 (corepressor interacting with RBPJ, 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cir1 (corepressor interacting with RBPJ, 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Homo sapiens (human):
CIR1 (corepressor interacting with RBPJ, 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
si:ch73-167c12.2
Alliance
DIOPT (Hieranoid, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG6843
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
cir-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Related Pseudogenes:
Gm13803
Gm18717
Gm18760
Gm2810
Gm5605
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 2 73,283,872 - 73,312,592 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 2 73,121,929 - 73,150,649 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 2 74,118,687 - 74,147,526 (-) NCBI mm8 MGSCv36 2 73,084,711 - 73,113,342 (-) NCBI mm8 Celera 2 74,973,472 - 74,999,133 (-) NCBI Celera Cytogenetic Map 2 C3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene Ontology Annotations
Biological Process
in utero embryonic development IMP MGI:MGI:5577261 2290270 (MGI:MGI:5888818, PMID:27996060) MGI MGI:MGI:5888818 , PMID:27996060 mRNA processing IEA UniProtKB-KW:KW-0507 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 negative regulation of transcription by RNA polymerase II ISO EMBL:AF098297 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 negative regulation of transcription, DNA-templated ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription, DNA-templated ISO EMBL:AF098297 2290270 (MGI:MGI:3609918, PMID:11591653) MGI MGI:MGI:3609918 , PMID:11591653 RNA splicing IEA UniProtKB-KW:KW-0508 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Cellular Component
centrosome colocalizes_with ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoskeleton IEA UniProtKB-KW:KW-0206 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nuclear speck ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nuclear speck ISO EMBL:AF098297 2290270 (MGI:MGI:3688359, PMID:15652350) MGI MGI:MGI:3688359 , PMID:15652350 nucleus ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO EMBL:AF098297 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 protein-containing complex ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Molecular Function
histone deacetylase binding ISO EMBL:AF098297 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 protein binding IPI UniProtKB:P97762 2290270 (MGI:MGI:3688359, PMID:15652350) IntAct MGI:MGI:3688359 , PMID:15652350 protein kinase binding ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex binding ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription corepressor activity ISO UniProtKB:Q86X95 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Molecular Pathway Annotations
Imported Annotations - KEGG (archival)
Notch signaling pathway IEA 6907045 KEGG mmu:04330
Phenotype Annotations
1300671 Cia4_m collagen induced arthritis QTL 4 (mouse) Not determined 2 43690268 77690412 Mouse 1301873 Hsl1_m hyperoxia susceptibility locus 1 (mouse) Not determined 2 63739810 97739957 Mouse 1301882 Etohc2_m ethanol consumption 2 (mouse) Not determined 2 68893925 102894063 Mouse 1301109 Dntcs2_m dental caries susceptibility 2 (mouse) Not determined 2 40995481 115079684 Mouse 1301660 Iba1_m induction of brown adipocytes 1 (mouse) Not determined 2 67817543 101817798 Mouse 1301948 Elsgp3_m elevated serum gp70 3 (mouse) Not determined 2 68893925 102894063 Mouse 1301344 Lith1_m lithogenic gene 1 (mouse) Not determined 2 45457623 145470727 Mouse 1301402 Ap2q_m alcohol preference 2 QTL (mouse) Not determined 2 43690268 77690412 Mouse 1301405 Etohr_m ethanol response acute (mouse) Not determined 2 63175610 97175769 Mouse 1301411 Pitm1_m prion incubation time 1 (mouse) Not determined 2 43690268 77690412 Mouse 1300662 Etohila_m ethanol induced locomotor activity (mouse) Not determined 2 63175610 97175769 Mouse 1301703 Bomd3_m bone mineral density 3 (mouse) Not determined 2 63175610 97175769 Mouse 1301747 Eae21_m experimental allergic encephalomyelitis 21 (mouse) Not determined 2 48439402 82439590 Mouse 1300761 Lgth1_m body length 1 (mouse) Not determined 2 51872932 85873081 Mouse 1301769 Orgwq2_m organ weight QTL 2 (mouse) Not determined 2 3886089 93591306 Mouse 1301235 Alcw4_m alcohol withdrawal 4 (mouse) Not determined 2 48439402 82439590 Mouse 1302085 Mobe1_m modifier of obesity 1 (mouse) Not determined 2 48439402 82439590 Mouse 1300788 Cia2_m collagen induced arthritis QTL 2 (mouse) Not determined 2 43690268 77690412 Mouse 1302174 Dssc2_m dextran sodium sulfate induced colitis QTL2 (mouse) Not determined 2 24334620 148858457 Mouse 1300568 Hdl1_m high density lipoprotein (HDL) level 1 (mouse) Not determined 2 48439402 82439590 Mouse 1300577 Capsq1_m capsaicin sensitivity related QTL 1 (mouse) Not determined 2 27712048 84183040 Mouse 1301480 Pbwg1_m postnatal body weight growth 1 (mouse) Not determined 2 41930707 75930831 Mouse 1300875 Taste1_m taste-saccharin preference 1 (mouse) Not determined 2 51092831 85092934 Mouse 1301048 Actre2_m activity response to ethanol 2 (mouse) Not determined 2 63175610 97175769 Mouse 1301059 Hrtfm1_m heart failure modifier 1 (mouse) Not determined 2 67761596 75134589 Mouse 1357881 Estoq1_m embryo survival total QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1357829 Lvrq1_m liver weight QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1357577 Trmq3_m T cell ratio modifier QTL 3 (mouse) Not determined 2 60690268 119525037 Mouse 1357681 Hrtq1_m heart weight QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1357436 Splq1_m spleen weight QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1357454 Kidq1_m kidney weight QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1558820 Moo1_m modifier of Odc1 (mouse) Not determined 17 48439402 82439590 Mouse 1558738 W6q1_m weight 6 weeks QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1558899 Egq1_m early growth QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1558915 W3q1_m weight 3 weeks QTL 1 (mouse) Not determined 2 20892967 119064359 Mouse 1558966 W10q9_m weight 10 weeks QTL 9 (mouse) Not determined 2 20892967 119064359 Mouse 4141809 Pbwg1.1_m postnatal body weight growth 1.1 (mouse) Not determined 48302068 82302151 Mouse 4141854 T2dm2sa_m type 2 diabetes mellitus 2 in SMXA RI mice (mouse) Not determined 2 29417935 148533014 Mouse 4141069 Pbwg1.5_m postnatal body weight growth 1.5 (mouse) Not determined 43690268 77690412 Mouse 4142299 Pbwg1.4_m postnatal body weight growth 1.4 (mouse) Not determined 55624072 89624172 Mouse 4141236 Hbnr5_m Heligmosomoides bakeri nematode resistance 5 (mouse) Not determined 31324555 105313225 Mouse 4141406 Alpq2_m alcohol preference QTL 2 (mouse) Not determined 2 57693773 91693944 Mouse 5491197 Mobq5_m multigenic obesity QTL 5 (mouse) Not determined 2 65439402 162677006 Mouse 10044002 Hdl7_m HDL level 7 (mouse) Not determined 2 63175610 97175769 Mouse 10053681 Lith24_m lithogenic gene 24 (mouse) Not determined 2 63175610 97175769 Mouse 10755526 Lymph1_m lymphocyte differential 1 (mouse) 2 50988970 84988970 Mouse 10755532 Lymph5_m lymphocyte differential 5 (mouse) 2 44368673 78368673 Mouse 11038703 Ltpr1_m Leishmania tropica response 1 (mouse) 2 40081653 74081799 Mouse 11532740 Pbwg1.10_m postnatal body weight growth 1.10 (mouse) 2 48302068 82302151 Mouse 12738429 Lfibq18_m liver fibrosis QTL 18 (mouse) 2 58089647 92089647 Mouse 13463471 Hctq6_m hematocrit QTL 6 (mouse) 2 52617675 86617792 Mouse 13463482 Mchq17_m mean corpuscular hemoglobin QTL 17 (mouse) 2 67817543 101817798 Mouse 13464141 Hbbcq3_m hemoglobin concentration QTL 3 (mouse) 2 52617675 86617792 Mouse 13824983 Vclq1_m curvilinear velocity QTL 1 (mouse) 2 62000000 137000000 Mouse
Predicted Target Of
Count of predictions: 396 Count of miRNA genes: 307 Interacting mature miRNAs: 341 Transcripts: ENSMUST00000058615, ENSMUST00000136519 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction