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Gene: PHC1 (polyhomeotic homolog 1) Homo sapiens
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Symbol: PHC1
Name: polyhomeotic homolog 1
Description: Predicted to have chromatin binding activity and histone binding activity. Involved in histone ubiquitination. Localizes to PRC1 complex and nucleoplasm. Implicated in primary autosomal recessive microcephaly 11.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: early development regulator 1 (homolog of polyhomeotic 1); early development regulatory protein 1; EDR1; HPH1; MCPH11; polyhomeotic 1-like; polyhomeotic-like 1; polyhomeotic-like protein 1; RAE28; Rae28-like
Orthologs:
Mus musculus (house mouse) : Phc1 (polyhomeotic 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phc1 (polyhomeotic homolog 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phc1 (polyhomeotic homolog 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PHC1 (polyhomeotic homolog 1)
Canis lupus familiaris (dog) : PHC1 (polyhomeotic homolog 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phc1 (polyhomeotic homolog 1)
Sus scrofa (pig) : PHC1 (polyhomeotic homolog 1)
Chlorocebus sabaeus (African green monkey) : PHC1 (polyhomeotic homolog 1)
Heterocephalus glaber (naked mole-rat) : Phc1 (polyhomeotic homolog 1)
more info ...
Related Pseudogenes: PHC1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl128,913,896 - 8,941,467 (+)EnsemblGRCh38hg38GRCh38
GRCh38128,914,509 - 8,941,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37129,067,292 - 9,094,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,958,583 - 8,985,330 (+)NCBINCBI36hg18NCBI36
Build 34128,958,532 - 8,984,156NCBI
Celera1210,604,723 - 10,631,471 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef128,847,980 - 8,874,662 (+)NCBIHuRef
CHM1_1129,036,292 - 9,063,026 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PHC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319414
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.