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Gene: Nthl1 (nth (endonuclease III)-like 1 (E.coli)) Mus musculus
Symbol: Nthl1
Name: nth (endonuclease III)-like 1 (E.coli)
CRRD ID: 1319555
Description: Exhibits DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in nucleotide-excision repair, DNA incision, 5'-to lesion. Localizes to mitochondrion and nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1); PARTICIPATES IN base excision repair pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; endonuclease III-like protein 1; Nth; Nth1; Octs3; thymine glycol DNA glycosylase/AP lyase
Homo sapiens (human) : NTHL1 (nth like DNA glycosylase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nthl1 (nth-like DNA glycosylase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nthl1 (nth like DNA glycosylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTHL1 (nth like DNA glycosylase 1)
Canis lupus familiaris (dog) : NTHL1 (nth like DNA glycosylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nthl1 (nth like DNA glycosylase 1)
Sus scrofa (pig) : NTHL1 (nth like DNA glycosylase 1)
Chlorocebus sabaeus (African green monkey) : NTHL1 (nth like DNA glycosylase 1)
Heterocephalus glaber (naked mole-rat) : Nthl1 (nth like DNA glycosylase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391724,851,654 - 24,857,812 (+)NCBI
GRCm381724,632,680 - 24,638,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,632,680 - 24,638,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,769,627 - 24,775,783 (+)NCBIGRCm37mm9NCBIm37
MGSCv361724,360,310 - 24,366,437 (+)NCBImm8
Celera1725,155,083 - 25,161,227 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nthl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319555
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.