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Gene: Spred2 (sprouty-related EVH1 domain containing 2) Mus musculus
Symbol: Spred2
Name: sprouty-related EVH1 domain containing 2
CRRD ID: 1319581
Description: Exhibits protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in positive regulation of DNA damage response, signal transduction by p53 class mediator and regulation of protein modification process. Localizes to cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: C79158; Spre; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related, EVH1 domain containing 2; sprouty-related, EVH1 domain-containing protein 2
Homo sapiens (human) : SPRED2 (sprouty related EVH1 domain containing 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spred2 (sprouty-related, EVH1 domain containing 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spred2 (sprouty related EVH1 domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRED2 (sprouty related EVH1 domain containing 2)
Canis lupus familiaris (dog) : SPRED2 (sprouty related EVH1 domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spred2 (sprouty related EVH1 domain containing 2)
Sus scrofa (pig) : SPRED2 (sprouty related EVH1 domain containing 2)
Chlorocebus sabaeus (African green monkey) : SPRED2 (sprouty related EVH1 domain containing 2)
Heterocephalus glaber (naked mole-rat) : Spred2 (sprouty related EVH1 domain containing 2)
more info ...
Related Pseudogenes: Gm14612  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1119,924,375 - 20,024,026 (+)EnsemblGRCm38mm10GRCm38
GRCm381119,924,442 - 20,024,026 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371119,824,445 - 19,922,600 (+)NCBIGRCm37mm9NCBIm37
MGSCv361119,824,445 - 19,922,600 (+)NCBImm8
Celera1122,066,219 - 22,164,240 (+)NCBICelera
Cytogenetic Map11A3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Spred2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319581
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.