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Gene: IRX4 (iroquois homeobox 4) Homo sapiens
Symbol: IRX4
Name: iroquois homeobox 4
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in establishment of animal organ orientation; heart development; and regulation of transcription by RNA polymerase II. Predicted to localize to the nuclear chromatin; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeodomain protein IRXA3; iroquois homeobox protein 4; iroquois-class homeodomain protein IRX-4; iroquois-class homeodomain protein IRX-4 variant 1; iroquois-class homeodomain protein IRX-4 variant 2; iroquois-class homeodomain protein IRX-4 variant 3; iroquois-class homeodomain protein IRX-4 variant 4; IRXA3; MGC131996
Mus musculus (house mouse) : Irx4 (Iroquois homeobox 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irx4 (iroquois homeobox 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irx4 (iroquois homeobox 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IRX4 (iroquois homeobox 4)
Canis lupus familiaris (dog) : IRX4 (iroquois homeobox 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irx4 (iroquois homeobox 4)
Sus scrofa (pig) : IRX4 (iroquois homeobox 4)
more info ...
Related Pseudogenes: IRX4P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl51,877,413 - 1,887,236 (-)Ensembl
GRCh3851,877,413 - 1,887,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3751,877,541 - 1,887,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,930,549 - 1,935,880 (-)NCBINCBI36hg18NCBI36
Build 3451,930,548 - 1,935,880NCBI
Celera51,914,716 - 1,920,055 (-)NCBI
Cytogenetic Map5p15.33NCBI
HuRef51,859,971 - 1,869,709 (-)NCBIHuRef
CHM1_151,877,411 - 1,887,153 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319589
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.