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Gene: Lrp5 (low density lipoprotein receptor-related protein 5) Mus musculus
Symbol: Lrp5
Name: low density lipoprotein receptor-related protein 5
CRRD ID: 1319618
Description: Exhibits Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; embryonic morphogenesis; and tube morphogenesis. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5); PARTICIPATES IN Wnt signaling, canonical pathway; altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BMND1; HBM; KIAA4142; L; low-density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 7; LR3; LRP-5; LRP-7; LRP7; mKIAA4142; OPPG
Homo sapiens (human) : LRP5 (LDL receptor related protein 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrp5 (LDL receptor related protein 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp5 (LDL receptor related protein 5)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP5 (LDL receptor related protein 5)
Canis lupus familiaris (dog) : LRP5 (LDL receptor related protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp5 (LDL receptor related protein 5)
Sus scrofa (pig) : LRP5 (LDL receptor related protein 5)
Chlorocebus sabaeus (African green monkey) : LRP5 (LDL receptor related protein 5)
Heterocephalus glaber (naked mole-rat) : Lrp5 (LDL receptor related protein 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39193,634,825 - 3,736,574 (-)NCBI
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrp5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319618
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.