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Gene: BCL6 (BCL6 transcription repressor) Homo sapiens
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Symbol: BCL6
Name: BCL6 transcription repressor
CRRD ID: 1319642
Description: Exhibits several functions, including DNA-binding transcription factor activity; chromatin binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cell growth; negative regulation of transcription by RNA polymerase II; and positive regulation of regulatory T cell differentiation. Localizes to Golgi apparatus and nucleoplasm. Colocalizes with replication fork. Implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Biomarker of diffuse large B-cell lymphoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B cell CLL/lymphoma 6; B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; BCL5; BCL6, transcription repressor; BCL6A; cys-his2 zinc finger transcription factor; LAZ3; lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; ZBTB27; zinc finger and BTB domain-containing protein 27; zinc finger protein 51; zinc finger transcription factor BCL6S; ZNF51
Orthologs:
Mus musculus (house mouse) : Bcl6 (B cell leukemia/lymphoma 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcl6 (BCL6, transcription repressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcl6 (BCL6 transcription repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : BCL6 (BCL6 transcription repressor)
Canis lupus familiaris (dog) : BCL6 (BCL6 transcription repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcl6 (BCL6 transcription repressor)
Sus scrofa (pig) : BCL6 (BCL6 transcription repressor)
Chlorocebus sabaeus (African green monkey) : BCL6 (BCL6 transcription repressor)
Heterocephalus glaber (naked mole-rat) : Bcl6 (BCL6 transcription repressor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3187,721,377 - 187,745,725 (-)EnsemblGRCh38hg38GRCh38
GRCh383187,721,377 - 187,745,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373187,439,165 - 187,463,513 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,921,859 - 188,946,169 (-)NCBINCBI36hg18NCBI36
Build 343188,921,866 - 188,936,950NCBI
Celera3185,870,167 - 185,894,514 (-)NCBI
Cytogenetic Map3q27.3NCBI
HuRef3184,843,368 - 184,867,718 (-)NCBIHuRef
CHM1_13187,402,407 - 187,426,738 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BCL6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319642
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.