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Gene: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1) Mus musculus
Symbol: Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Description: Exhibits 14-3-3 protein binding activity. Involved in several processes, including growth; regulation of DNA damage checkpoint; and response to ionizing radiation. Localizes to the centrosome and nucleus. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Is expressed in several structures, including central nervous system; ganglia; gonad; lung; and spleen. Orthologous to human NEK1 (NIMA related kinase 1); INTERACTS WITH cadmium dichloride; mono(2-ethylhexyl) phthalate; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D8Ertd790e; kat; kidney, anemia and testis; MGC189817; Nek1 serine/threonine- and tyrosine-specific protein kinase; never in mitosis A-related kinase 1; NIMA-related kinase 1; nimA-related protein kinase 1; NY-REN-55 antigen; serine/threonine-protein kinase Nek1
Homo sapiens (human) : NEK1 (NIMA related kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nek1 (NIMA-related kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nek1 (NIMA related kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NEK1 (NIMA related kinase 1)
Canis lupus familiaris (dog) : NEK1 (NIMA related kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nek1 (NIMA related kinase 1)
Sus scrofa (pig) : NEK1 (NIMA related kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBImm8
Celera863,560,363 - 63,697,492 (+)NCBICelera
Cytogenetic Map8 B3.1NCBI
cM Map830.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nek1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319691
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.