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Gene: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1) Mus musculus
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Symbol: Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Description: Exhibits 14-3-3 protein binding activity. Involved in several processes, including growth; regulation of DNA damage checkpoint; and response to ionizing radiation. Localizes to the centrosome and nucleus. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Is expressed in several structures, including central nervous system; ganglia; gonad; lung; and spleen. Orthologous to human NEK1 (NIMA related kinase 1); INTERACTS WITH cadmium dichloride; mono(2-ethylhexyl) phthalate; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D8Ertd790e; kat; kidney, anemia and testis; MGC189817; Nek1 serine/threonine- and tyrosine-specific protein kinase; never in mitosis A-related kinase 1; NIMA-related kinase 1; nimA-related protein kinase 1; NY-REN-55 antigen; serine/threonine-protein kinase Nek1
Orthologs:
Homo sapiens (human) : NEK1 (NIMA related kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nek1 (NIMA-related kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nek1 (NIMA related kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NEK1 (NIMA related kinase 1)
Canis lupus familiaris (dog) : NEK1 (NIMA related kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nek1 (NIMA related kinase 1)
Sus scrofa (pig) : NEK1 (NIMA related kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBImm8
Celera863,560,363 - 63,697,492 (+)NCBICelera
Cytogenetic Map8 B3.1NCBI
cM Map830.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nek1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319691
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.