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Gene: GPR35 (G protein-coupled receptor 35) Homo sapiens
Symbol: GPR35
Name: G protein-coupled receptor 35
Description: Exhibits C-X-C chemokine receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Localizes to the integral component of plasma membrane; INTERACTS WITH 1,4-dihydroxy-2-naphthoic acid; 3-Hydroxy-2-naphthoate; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-protein coupled receptor 35; KYNA receptor; kynurenic acid receptor
Mus musculus (house mouse) : Gpr35 (G protein-coupled receptor 35)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpr35 (G protein-coupled receptor 35)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpr35 (G protein-coupled receptor 35)
Pan paniscus (bonobo/pygmy chimpanzee) : GPR35 (G protein-coupled receptor 35)
Canis lupus familiaris (dog) : LOC100855802 (G-protein coupled receptor 35-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpr35 (G protein-coupled receptor 35)
Sus scrofa (pig) : GPR35 (G protein-coupled receptor 35)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2240,605,430 - 240,631,259 (+)Ensembl
GRCh382240,605,430 - 240,631,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,544,825 - 241,570,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,217,468 - 241,219,342 (+)NCBINCBI36hg18NCBI36
Build 342241,288,784 - 241,290,659NCBI
Celera2235,241,148 - 235,243,022 (+)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2233,301,477 - 233,329,054 (+)NCBIHuRef
CHM1_12241,550,880 - 241,576,585 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GPR35
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319732
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.