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Gene: KDM2A (lysine demethylase 2A) Homo sapiens
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Symbol: KDM2A
Name: lysine demethylase 2A
CRRD ID: 1319753
Description: Exhibits histone demethylase activity (H3-K36 specific); unmethylated CpG binding activity; and zinc ion binding activity. Involved in several processes, including double-strand break repair via nonhomologous end joining; histone H3-K36 demethylation; and regulation of gene expression. Predicted to localize to nuclear chromatin. Implicated in lung non-small cell carcinoma. Biomarker of lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Histone-H3]-lysine-36 demethylase 1A; CXXC-type zinc finger protein 8; CXXC8; DKFZp434M1735; F-box and leucine-rich repeat protein 11; F-box protein FBL11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; FBL11; FBL7; FBXL11; FLJ00115; FLJ46431; JHDM1A; jmjC domain-containing histone demethylation protein 1A; jumonji C domain-containing histone demethylase 1A; KIAA1004; LILINA; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A; SF-KDM2A
Orthologs:
Mus musculus (house mouse) : Kdm2a (lysine (K)-specific demethylase 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm2a (lysine demethylase 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm2a (lysine demethylase 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM2A (lysine demethylase 2A)
Canis lupus familiaris (dog) : KDM2A (lysine demethylase 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm2a (lysine demethylase 2A)
Sus scrofa (pig) : KDM2A (lysine demethylase 2A)
Chlorocebus sabaeus (African green monkey) : KDM2A (lysine demethylase 2A)
Heterocephalus glaber (naked mole-rat) : Kdm2a (lysine demethylase 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1167,119,263 - 67,258,082 (+)EnsemblGRCh38hg38GRCh38
GRCh381167,119,263 - 67,258,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,886,740 - 67,025,553 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,644,074 - 66,781,717 (+)NCBINCBI36hg18NCBI36
Build 341166,644,073 - 66,781,717NCBI
Celera1164,216,493 - 64,358,014 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1163,214,819 - 63,354,668 (+)NCBIHuRef
CHM1_11166,769,756 - 66,908,574 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KDM2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1319753
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.